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Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy arising from plasmacytoid dendritic cell precursors. The disease typically manifests in the skin, but it also evolves into a leukemic phase or can be complicated by other myeloid malignancies, especi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687125/ https://www.ncbi.nlm.nih.gov/pubmed/32374950 http://dx.doi.org/10.1002/dc.24463 |
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author | Yan, Miao Wang, Wensheng Cen, Xinan Wang, Lihong Sun, Yuhua Wang, Bingjie Ou, Jinping Nong, Lin Ren, Hanyun Zhu, Ping Wang, Mangju |
author_facet | Yan, Miao Wang, Wensheng Cen, Xinan Wang, Lihong Sun, Yuhua Wang, Bingjie Ou, Jinping Nong, Lin Ren, Hanyun Zhu, Ping Wang, Mangju |
author_sort | Yan, Miao |
collection | PubMed |
description | Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy arising from plasmacytoid dendritic cell precursors. The disease typically manifests in the skin, but it also evolves into a leukemic phase or can be complicated by other myeloid malignancies, especially myelomonocytic tumors. The association between these neoplasms is not fully elucidated. We report a case of BPDCN with a history of cytopenia that was supposed to be chronic myelomonocytic leukemia. The patient received intensive chemotherapy and achieved complete remission, but soon relapsed. The successive occurrence of myelomonocytic neoplasm and BPDCN is in accordance with the fact that they evolve from a common cell origin with a multilineage potential for myelomonocytic and plasmacytoid dendritic cell differentiation. This case may shed further light on the mystery of biology and the histogenesis of BPDCN. |
format | Online Article Text |
id | pubmed-7687125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76871252020-12-03 Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report Yan, Miao Wang, Wensheng Cen, Xinan Wang, Lihong Sun, Yuhua Wang, Bingjie Ou, Jinping Nong, Lin Ren, Hanyun Zhu, Ping Wang, Mangju Diagn Cytopathol Brief Reports Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy arising from plasmacytoid dendritic cell precursors. The disease typically manifests in the skin, but it also evolves into a leukemic phase or can be complicated by other myeloid malignancies, especially myelomonocytic tumors. The association between these neoplasms is not fully elucidated. We report a case of BPDCN with a history of cytopenia that was supposed to be chronic myelomonocytic leukemia. The patient received intensive chemotherapy and achieved complete remission, but soon relapsed. The successive occurrence of myelomonocytic neoplasm and BPDCN is in accordance with the fact that they evolve from a common cell origin with a multilineage potential for myelomonocytic and plasmacytoid dendritic cell differentiation. This case may shed further light on the mystery of biology and the histogenesis of BPDCN. John Wiley & Sons, Inc. 2020-05-06 2020-11 /pmc/articles/PMC7687125/ /pubmed/32374950 http://dx.doi.org/10.1002/dc.24463 Text en © 2020 The Authors. Diagnostic Cytopathology published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Reports Yan, Miao Wang, Wensheng Cen, Xinan Wang, Lihong Sun, Yuhua Wang, Bingjie Ou, Jinping Nong, Lin Ren, Hanyun Zhu, Ping Wang, Mangju Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report |
title | Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report |
title_full | Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report |
title_fullStr | Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report |
title_full_unstemmed | Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report |
title_short | Blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: A case report |
title_sort | blastic plasmacytoid dendritic cell neoplasm with a history of cytopenia: a case report |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687125/ https://www.ncbi.nlm.nih.gov/pubmed/32374950 http://dx.doi.org/10.1002/dc.24463 |
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