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Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament

BACKGROUND: Autonomic hyperarousal has been proposed as a dispositional risk factor for anxiety disorders (ADs). Therefore, we studied physiological arousal in offspring of fathers and mothers with and without ADs and whether infant hyperarousal predicts subsequent fearful temperament. METHODS: Infa...

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Autores principales: de Vente, Wieke, Majdandžić, Mirjana, Bögels, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687129/
https://www.ncbi.nlm.nih.gov/pubmed/31994221
http://dx.doi.org/10.1111/jcpp.13208
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author de Vente, Wieke
Majdandžić, Mirjana
Bögels, Susan M.
author_facet de Vente, Wieke
Majdandžić, Mirjana
Bögels, Susan M.
author_sort de Vente, Wieke
collection PubMed
description BACKGROUND: Autonomic hyperarousal has been proposed as a dispositional risk factor for anxiety disorders (ADs). Therefore, we studied physiological arousal in offspring of fathers and mothers with and without ADs and whether infant hyperarousal predicts subsequent fearful temperament. METHODS: Infants (N = 128; age = 4 months) did a novel stimuli task (exposure to visual, olfactory, and acoustic stimuli and an unfamiliar male) and a habituation task (exposure to a repeated acoustic stimulus). Heart rate (HR) and heart rate variability (HRV) were measured during baseline, stimuli and post‐stimuli rest. Parents’ AD status and severity were measured using a diagnostic interview and their fearful temperament using a questionnaire. Child fearful temperament was measured at 4 months, 1 year and 2.5 years with observations during structured tasks. RESULTS: Parents’ fearful temperament (significant in the habituation task), AD status (significant in the novel stimuli task) and AD severity (significant in both tasks) predicted a higher HR in their infants. Infants’ higher HR reactivity to novel stimuli and diminished HR recovery at 4 months predicted a more fearful temperament during infancy and toddlerhood. Infants’ higher HR at 4 months predicted a more fearful temperament at 2.5 years. CONCLUSIONS: Parental prenatal anxiety (disorders) predicted infants’ autonomic arousal, which in turn predicted later fearful temperament in children. Outcomes suggest that autonomic hyperarousal is a dispositional risk factor of ADs.
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spelling pubmed-76871292020-12-03 Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament de Vente, Wieke Majdandžić, Mirjana Bögels, Susan M. J Child Psychol Psychiatry Original Articles BACKGROUND: Autonomic hyperarousal has been proposed as a dispositional risk factor for anxiety disorders (ADs). Therefore, we studied physiological arousal in offspring of fathers and mothers with and without ADs and whether infant hyperarousal predicts subsequent fearful temperament. METHODS: Infants (N = 128; age = 4 months) did a novel stimuli task (exposure to visual, olfactory, and acoustic stimuli and an unfamiliar male) and a habituation task (exposure to a repeated acoustic stimulus). Heart rate (HR) and heart rate variability (HRV) were measured during baseline, stimuli and post‐stimuli rest. Parents’ AD status and severity were measured using a diagnostic interview and their fearful temperament using a questionnaire. Child fearful temperament was measured at 4 months, 1 year and 2.5 years with observations during structured tasks. RESULTS: Parents’ fearful temperament (significant in the habituation task), AD status (significant in the novel stimuli task) and AD severity (significant in both tasks) predicted a higher HR in their infants. Infants’ higher HR reactivity to novel stimuli and diminished HR recovery at 4 months predicted a more fearful temperament during infancy and toddlerhood. Infants’ higher HR at 4 months predicted a more fearful temperament at 2.5 years. CONCLUSIONS: Parental prenatal anxiety (disorders) predicted infants’ autonomic arousal, which in turn predicted later fearful temperament in children. Outcomes suggest that autonomic hyperarousal is a dispositional risk factor of ADs. John Wiley and Sons Inc. 2020-01-28 2020-11 /pmc/articles/PMC7687129/ /pubmed/31994221 http://dx.doi.org/10.1111/jcpp.13208 Text en © 2020 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
de Vente, Wieke
Majdandžić, Mirjana
Bögels, Susan M.
Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
title Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
title_full Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
title_fullStr Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
title_full_unstemmed Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
title_short Intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
title_sort intergenerational transmission of anxiety: linking parental anxiety to infant autonomic hyperarousal and fearful temperament
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687129/
https://www.ncbi.nlm.nih.gov/pubmed/31994221
http://dx.doi.org/10.1111/jcpp.13208
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