Shell‐by‐Shell Functionalization of Inorganic Nanoparticles

The current state of the hierarchical chemical functionalization of inorganic nanoparticles (NPs) by shell‐by‐shell (SbS)‐assembly of organic layers around the NP cores is summarized. This supramolecular functionalization concept is based on two steps: 1) the covalent grafting of a first ligand–shell consisting of, for example, long chain phosphonic acids and 2) the noncovalent interdigitation of amphiphiles forming the second ligand shell. The latter process is guaranteed predominantly by solvophobic interactions. These highly order organic–inorganic hybrid architectures are currently an emerging field at the interface of synthetic chemistry, nanotechnology, and materials science. The doubly functionalized NPs display tunable materials properties, such a controlled dispersibility and stability in various solvents, highly efficient trapping of guest molecules in between the ligand shells (water cleaning) as well as compartmentalization and modification of electronic interactions between photoactive components integrated in such complex nano‐architectures. Such SbS‐functionalized NPs have a high potential as water‐cleaning materials and also some first prototype applications as biomedicinal therapeutics have been presented.