Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria

New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light‐activated rhenium complex with activity agai...

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Detalles Bibliográficos
Autores principales: Frei, Angelo, Amado, Maite, Cooper, Matthew A., Blaskovich, Mark A. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687258/
https://www.ncbi.nlm.nih.gov/pubmed/31788867
http://dx.doi.org/10.1002/chem.201904689
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author Frei, Angelo
Amado, Maite
Cooper, Matthew A.
Blaskovich, Mark A. T.
author_facet Frei, Angelo
Amado, Maite
Cooper, Matthew A.
Blaskovich, Mark A. T.
author_sort Frei, Angelo
collection PubMed
description New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light‐activated rhenium complex with activity against drug‐resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.
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spelling pubmed-76872582020-12-05 Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria Frei, Angelo Amado, Maite Cooper, Matthew A. Blaskovich, Mark A. T. Chemistry Full Papers New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light‐activated rhenium complex with activity against drug‐resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action. John Wiley and Sons Inc. 2020-01-30 2020-03-02 /pmc/articles/PMC7687258/ /pubmed/31788867 http://dx.doi.org/10.1002/chem.201904689 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Frei, Angelo
Amado, Maite
Cooper, Matthew A.
Blaskovich, Mark A. T.
Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
title Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
title_full Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
title_fullStr Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
title_full_unstemmed Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
title_short Light‐Activated Rhenium Complexes with Dual Mode of Action against Bacteria
title_sort light‐activated rhenium complexes with dual mode of action against bacteria
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687258/
https://www.ncbi.nlm.nih.gov/pubmed/31788867
http://dx.doi.org/10.1002/chem.201904689
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