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Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis

BACKGROUND: Evidence suggests lungs as the organ most affected by coronavirus disease 2019 (COVID-19). The literature on previous coronavirus infections reports that patients may experience persistent impairment in respiratory function after being discharged. Our objective was to determine the preva...

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Autores principales: Torres-Castro, R., Vasconcello-Castillo, L., Alsina-Restoy, X., Solis-Navarro, L., Burgos, F., Puppo, H., Vilaró, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687368/
https://www.ncbi.nlm.nih.gov/pubmed/33262076
http://dx.doi.org/10.1016/j.pulmoe.2020.10.013
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author Torres-Castro, R.
Vasconcello-Castillo, L.
Alsina-Restoy, X.
Solis-Navarro, L.
Burgos, F.
Puppo, H.
Vilaró, J.
author_facet Torres-Castro, R.
Vasconcello-Castillo, L.
Alsina-Restoy, X.
Solis-Navarro, L.
Burgos, F.
Puppo, H.
Vilaró, J.
author_sort Torres-Castro, R.
collection PubMed
description BACKGROUND: Evidence suggests lungs as the organ most affected by coronavirus disease 2019 (COVID-19). The literature on previous coronavirus infections reports that patients may experience persistent impairment in respiratory function after being discharged. Our objective was to determine the prevalence of restrictive pattern, obstructive pattern and altered diffusion in patients post-COVID-19 infection and to describe the different evaluations of respiratory function used with these patients. METHODS: A systematic review was conducted in five databases. Studies that used lung function testing to assess post-infection COVID-19 patients were included for review. Two independent reviewers analysed the studies, extracted the data and assessed the quality of evidence. RESULTS: Of the 1973 reports returned by the initial search, seven articles reporting on 380 patients were included in the data synthesis. In the sensitivity analysis, we found a prevalence of 0.39 (CI 0.24–0.56, p < 0.01, I(2) = 86%), 0.15 (CI 0.09–0.22, p = 0.03, I(2) = 59%), and 0.07 (CI 0.04–0.11, p = 0.31, I(2) = 16%) for altered diffusion capacity of the lungs for carbon monoxide (DL(CO)), restrictive pattern and obstructive pattern, respectively. CONCLUSION: Post-infection COVID-19 patients showed impaired lung function; the most important of the pulmonary function tests affected was the diffusion capacity.
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spelling pubmed-76873682020-11-25 Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis Torres-Castro, R. Vasconcello-Castillo, L. Alsina-Restoy, X. Solis-Navarro, L. Burgos, F. Puppo, H. Vilaró, J. Pulmonology Review BACKGROUND: Evidence suggests lungs as the organ most affected by coronavirus disease 2019 (COVID-19). The literature on previous coronavirus infections reports that patients may experience persistent impairment in respiratory function after being discharged. Our objective was to determine the prevalence of restrictive pattern, obstructive pattern and altered diffusion in patients post-COVID-19 infection and to describe the different evaluations of respiratory function used with these patients. METHODS: A systematic review was conducted in five databases. Studies that used lung function testing to assess post-infection COVID-19 patients were included for review. Two independent reviewers analysed the studies, extracted the data and assessed the quality of evidence. RESULTS: Of the 1973 reports returned by the initial search, seven articles reporting on 380 patients were included in the data synthesis. In the sensitivity analysis, we found a prevalence of 0.39 (CI 0.24–0.56, p < 0.01, I(2) = 86%), 0.15 (CI 0.09–0.22, p = 0.03, I(2) = 59%), and 0.07 (CI 0.04–0.11, p = 0.31, I(2) = 16%) for altered diffusion capacity of the lungs for carbon monoxide (DL(CO)), restrictive pattern and obstructive pattern, respectively. CONCLUSION: Post-infection COVID-19 patients showed impaired lung function; the most important of the pulmonary function tests affected was the diffusion capacity. Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. 2021 2020-11-25 /pmc/articles/PMC7687368/ /pubmed/33262076 http://dx.doi.org/10.1016/j.pulmoe.2020.10.013 Text en © 2020 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Torres-Castro, R.
Vasconcello-Castillo, L.
Alsina-Restoy, X.
Solis-Navarro, L.
Burgos, F.
Puppo, H.
Vilaró, J.
Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
title Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
title_full Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
title_fullStr Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
title_full_unstemmed Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
title_short Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis
title_sort respiratory function in patients post-infection by covid-19: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687368/
https://www.ncbi.nlm.nih.gov/pubmed/33262076
http://dx.doi.org/10.1016/j.pulmoe.2020.10.013
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