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What can we learn from brain autopsies in COVID-19?

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) for which there have been over 50 million confirmed cases and 1.2 million deaths globally. While many SARS-CoV-2 infected individuals are asymptomatic or experience respiratory...

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Detalles Bibliográficos
Autores principales: Mukerji, Shibani S., Solomon, Isaac H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687409/
https://www.ncbi.nlm.nih.gov/pubmed/33248159
http://dx.doi.org/10.1016/j.neulet.2020.135528
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author Mukerji, Shibani S.
Solomon, Isaac H.
author_facet Mukerji, Shibani S.
Solomon, Isaac H.
author_sort Mukerji, Shibani S.
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description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) for which there have been over 50 million confirmed cases and 1.2 million deaths globally. While many SARS-CoV-2 infected individuals are asymptomatic or experience respiratory symptoms, extrapulmonary manifestations, including neurological symptoms and conditions, are increasingly recognized. There remains no clear understanding of the mechanisms that underlie neurological symptoms in COVID-19 and whether SARS-CoV-2 has the potential for neuroinvasion in humans. In this minireview, we discuss what is known from human autopsies in fatal COVID-19, including highlighting studies that investigate for the presence of SARS-CoV-2 in brain and olfactory tissue, and summarize the neuropathological consequences of infection. Incorporating microscopic and molecular findings from brain tissue into what we know about clinical disease will inform best practice management guidance and direct research priorities as it relates to neurological morbidity from COVID-19.
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spelling pubmed-76874092020-11-25 What can we learn from brain autopsies in COVID-19? Mukerji, Shibani S. Solomon, Isaac H. Neurosci Lett Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) for which there have been over 50 million confirmed cases and 1.2 million deaths globally. While many SARS-CoV-2 infected individuals are asymptomatic or experience respiratory symptoms, extrapulmonary manifestations, including neurological symptoms and conditions, are increasingly recognized. There remains no clear understanding of the mechanisms that underlie neurological symptoms in COVID-19 and whether SARS-CoV-2 has the potential for neuroinvasion in humans. In this minireview, we discuss what is known from human autopsies in fatal COVID-19, including highlighting studies that investigate for the presence of SARS-CoV-2 in brain and olfactory tissue, and summarize the neuropathological consequences of infection. Incorporating microscopic and molecular findings from brain tissue into what we know about clinical disease will inform best practice management guidance and direct research priorities as it relates to neurological morbidity from COVID-19. Elsevier B.V. 2021-01-18 2020-11-25 /pmc/articles/PMC7687409/ /pubmed/33248159 http://dx.doi.org/10.1016/j.neulet.2020.135528 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mukerji, Shibani S.
Solomon, Isaac H.
What can we learn from brain autopsies in COVID-19?
title What can we learn from brain autopsies in COVID-19?
title_full What can we learn from brain autopsies in COVID-19?
title_fullStr What can we learn from brain autopsies in COVID-19?
title_full_unstemmed What can we learn from brain autopsies in COVID-19?
title_short What can we learn from brain autopsies in COVID-19?
title_sort what can we learn from brain autopsies in covid-19?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687409/
https://www.ncbi.nlm.nih.gov/pubmed/33248159
http://dx.doi.org/10.1016/j.neulet.2020.135528
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