Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor. Most DIPGs harbor a histone H3 mutation, which alters histone post-translational modification (PTM) states and transcription. Here, we employed quantitative proteomic analysis to elucidate the impact of t...

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Detalles Bibliográficos
Autores principales: An, Shejuan, Camarillo, Jeannie M., Huang, Tina Yi-Ting, Li, Daphne, Morris, Juliette A., Zoltek, Madeline A., Qi, Jin, Behbahani, Mandana, Kambhampati, Madhuri, Kelleher, Neil L., Nazarian, Javad, Thomas, Paul M., Saratsis, Amanda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687710/
https://www.ncbi.nlm.nih.gov/pubmed/33239043
http://dx.doi.org/10.1186/s13046-020-01773-x

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