The role of mitophagy in innate immune responses triggered by mitochondrial stress

ABSTRACT: Mitochondria are important cellular organelles involved in many different functions, from energy generation and fatty acid oxidation to cell death regulation and immune responses. Accumulating evidence indicates that mitochondrial stress acts as a key trigger of innate immune responses. Cr...

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Detalles Bibliográficos
Autores principales: Song, Yinjuan, Zhou, Yang, Zhou, Xiangmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687798/
https://www.ncbi.nlm.nih.gov/pubmed/33239048
http://dx.doi.org/10.1186/s12964-020-00659-x
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author Song, Yinjuan
Zhou, Yang
Zhou, Xiangmei
author_facet Song, Yinjuan
Zhou, Yang
Zhou, Xiangmei
author_sort Song, Yinjuan
collection PubMed
description ABSTRACT: Mitochondria are important cellular organelles involved in many different functions, from energy generation and fatty acid oxidation to cell death regulation and immune responses. Accumulating evidence indicates that mitochondrial stress acts as a key trigger of innate immune responses. Critically, the dysfunctional mitochondria can be selectively eliminated by mitophagy. The elimination of dysfunctional mitochondria may function as an effective way employed by mitophagy to keep the immune system in check. In addition, mitophagy can be utilized by pathogens for immune evasion. In this review, we summarize how mitochondrial stress triggers innate immune responses and the roles of mitophagy in innate immunity and in infection, as well as the molecular mechanisms of mitophagy. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-76877982020-11-30 The role of mitophagy in innate immune responses triggered by mitochondrial stress Song, Yinjuan Zhou, Yang Zhou, Xiangmei Cell Commun Signal Review ABSTRACT: Mitochondria are important cellular organelles involved in many different functions, from energy generation and fatty acid oxidation to cell death regulation and immune responses. Accumulating evidence indicates that mitochondrial stress acts as a key trigger of innate immune responses. Critically, the dysfunctional mitochondria can be selectively eliminated by mitophagy. The elimination of dysfunctional mitochondria may function as an effective way employed by mitophagy to keep the immune system in check. In addition, mitophagy can be utilized by pathogens for immune evasion. In this review, we summarize how mitochondrial stress triggers innate immune responses and the roles of mitophagy in innate immunity and in infection, as well as the molecular mechanisms of mitophagy. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2020-11-25 /pmc/articles/PMC7687798/ /pubmed/33239048 http://dx.doi.org/10.1186/s12964-020-00659-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Song, Yinjuan
Zhou, Yang
Zhou, Xiangmei
The role of mitophagy in innate immune responses triggered by mitochondrial stress
title The role of mitophagy in innate immune responses triggered by mitochondrial stress
title_full The role of mitophagy in innate immune responses triggered by mitochondrial stress
title_fullStr The role of mitophagy in innate immune responses triggered by mitochondrial stress
title_full_unstemmed The role of mitophagy in innate immune responses triggered by mitochondrial stress
title_short The role of mitophagy in innate immune responses triggered by mitochondrial stress
title_sort role of mitophagy in innate immune responses triggered by mitochondrial stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687798/
https://www.ncbi.nlm.nih.gov/pubmed/33239048
http://dx.doi.org/10.1186/s12964-020-00659-x
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