Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone

Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to type 2 diabetes (T2D). The antioxidant α-lipoic acid (ALA) has been shown to attenuate metaboli...

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Detalles Bibliográficos
Autores principales: Diane, Abdoulaye, Mahmoud, Naela, Bensmail, Ilham, Khattab, Namat, Abunada, Hanan A., Dehbi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687893/
https://www.ncbi.nlm.nih.gov/pubmed/33235302
http://dx.doi.org/10.1038/s41598-020-77621-x

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