A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations

A 67-year-old female with a history of colon cancer underwent colonoscopy. An 8 mm semi-pedunculated, friable, and ulcerated lesion of the ascending colon was removed completely using a hot snare. Immunohistochemical staining showed strong positivity for transcription factor binding to IGHM enhancer...

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Detalles Bibliográficos
Autores principales: Bennett, Joseph, Laury, Raquele, Dai, Hongyan, Walde, Charles, Kasi, Anup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688055/
https://www.ncbi.nlm.nih.gov/pubmed/33251071
http://dx.doi.org/10.7759/cureus.11164
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author Bennett, Joseph
Laury, Raquele
Dai, Hongyan
Walde, Charles
Kasi, Anup
author_facet Bennett, Joseph
Laury, Raquele
Dai, Hongyan
Walde, Charles
Kasi, Anup
author_sort Bennett, Joseph
collection PubMed
description A 67-year-old female with a history of colon cancer underwent colonoscopy. An 8 mm semi-pedunculated, friable, and ulcerated lesion of the ascending colon was removed completely using a hot snare. Immunohistochemical staining showed strong positivity for transcription factor binding to IGHM enhancer 3 (TFE-3) and was partially positive for Human Melanoma Black (HMB-45), consistent with a diagnosis of perivascular epithelioid cell tumor (PEComa). The patient underwent endoscopic submucosal dissection of the residual lesion in the ascending colon without complications. Here, we discuss the clinical and histopathologic characterizations that helped guide the diagnosis and management of this exceedingly rare entity.
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spelling pubmed-76880552020-11-27 A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations Bennett, Joseph Laury, Raquele Dai, Hongyan Walde, Charles Kasi, Anup Cureus Internal Medicine A 67-year-old female with a history of colon cancer underwent colonoscopy. An 8 mm semi-pedunculated, friable, and ulcerated lesion of the ascending colon was removed completely using a hot snare. Immunohistochemical staining showed strong positivity for transcription factor binding to IGHM enhancer 3 (TFE-3) and was partially positive for Human Melanoma Black (HMB-45), consistent with a diagnosis of perivascular epithelioid cell tumor (PEComa). The patient underwent endoscopic submucosal dissection of the residual lesion in the ascending colon without complications. Here, we discuss the clinical and histopathologic characterizations that helped guide the diagnosis and management of this exceedingly rare entity. Cureus 2020-10-26 /pmc/articles/PMC7688055/ /pubmed/33251071 http://dx.doi.org/10.7759/cureus.11164 Text en Copyright © 2020, Bennett et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Bennett, Joseph
Laury, Raquele
Dai, Hongyan
Walde, Charles
Kasi, Anup
A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations
title A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations
title_full A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations
title_fullStr A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations
title_full_unstemmed A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations
title_short A Curious Case of Colonic Perivascular Epithelioid Cell Tumor: A Unique Diagnosis With Variable Presentations
title_sort curious case of colonic perivascular epithelioid cell tumor: a unique diagnosis with variable presentations
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688055/
https://www.ncbi.nlm.nih.gov/pubmed/33251071
http://dx.doi.org/10.7759/cureus.11164
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