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Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy
PURPOSE: To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD). METHODS: 45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects w...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688121/ https://www.ncbi.nlm.nih.gov/pubmed/33237913 http://dx.doi.org/10.1371/journal.pone.0239124 |
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author | Buffault, Juliette Zéboulon, Pierre Liang, Hong Chiche, Anthony Luzu, Jade Robin, Mathieu Rabut, Ghislaine Labetoulle, Marc Labbé, Antoine Baudouin, Christophe |
author_facet | Buffault, Juliette Zéboulon, Pierre Liang, Hong Chiche, Anthony Luzu, Jade Robin, Mathieu Rabut, Ghislaine Labetoulle, Marc Labbé, Antoine Baudouin, Christophe |
author_sort | Buffault, Juliette |
collection | PubMed |
description | PURPOSE: To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD). METHODS: 45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects were enrolled. All participants were subjected to 9-mm corneal epithelial mapping with OCT and vision quality was assessed with the optical quality analysis system using the objective scatter index (OSI). Central, superior, inferior, minimum, maximum, and standard deviation of epithelium thickness (Irregularity), were analysed and correlations with the OSI were calculated. RESULTS: The mean (±SD) central, inferior and maximum epithelial thicknesses of the EBMD patients (respectively, 56.4 (±8.1) μm, 58.9 (±6.4) μm, and 67.1 (±8.3) μm) were thicker compared to DED patients (P<0.05) and normal subjects (P<0.05). We found greater irregularity of epithelial thickness in EBMD (5.1±2.5 μm) compared to DED patients (2.6±1.0 μm) (P = 4.4.10(−6)) and normal subjects (2.1±0.7 μm) (P = 7.6.10(−7)). The mean OSI was worse in EBMD patients than in DED patients (P = 0.01) and compared to normal subjects (P = 0.02). The OSI correlated with the epithelial thickness irregularity (Spearman coefficient = 0.54; P = 2.65.10(−5)). CONCLUSIONS: The OCT pachymetry map demonstrated that EBMD patients had thicker corneal epithelium in the central and inferior region. These changes were correlated with objective measurements of vision quality. This OCT characterisation of the EMBD provides a better understanding of the epithelial behaviour in this dystrophy and its role in vision quality. |
format | Online Article Text |
id | pubmed-7688121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76881212020-12-05 Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy Buffault, Juliette Zéboulon, Pierre Liang, Hong Chiche, Anthony Luzu, Jade Robin, Mathieu Rabut, Ghislaine Labetoulle, Marc Labbé, Antoine Baudouin, Christophe PLoS One Research Article PURPOSE: To investigate the corneal epithelial thickness topography with optical coherence tomography (OCT) and its relationship with vision quality in epithelial basement membrane dystrophy (EBMD). METHODS: 45 eyes of EBMD patients, 26 eyes of dry eye (DED) patients and 22 eyes of normal subjects were enrolled. All participants were subjected to 9-mm corneal epithelial mapping with OCT and vision quality was assessed with the optical quality analysis system using the objective scatter index (OSI). Central, superior, inferior, minimum, maximum, and standard deviation of epithelium thickness (Irregularity), were analysed and correlations with the OSI were calculated. RESULTS: The mean (±SD) central, inferior and maximum epithelial thicknesses of the EBMD patients (respectively, 56.4 (±8.1) μm, 58.9 (±6.4) μm, and 67.1 (±8.3) μm) were thicker compared to DED patients (P<0.05) and normal subjects (P<0.05). We found greater irregularity of epithelial thickness in EBMD (5.1±2.5 μm) compared to DED patients (2.6±1.0 μm) (P = 4.4.10(−6)) and normal subjects (2.1±0.7 μm) (P = 7.6.10(−7)). The mean OSI was worse in EBMD patients than in DED patients (P = 0.01) and compared to normal subjects (P = 0.02). The OSI correlated with the epithelial thickness irregularity (Spearman coefficient = 0.54; P = 2.65.10(−5)). CONCLUSIONS: The OCT pachymetry map demonstrated that EBMD patients had thicker corneal epithelium in the central and inferior region. These changes were correlated with objective measurements of vision quality. This OCT characterisation of the EMBD provides a better understanding of the epithelial behaviour in this dystrophy and its role in vision quality. Public Library of Science 2020-11-25 /pmc/articles/PMC7688121/ /pubmed/33237913 http://dx.doi.org/10.1371/journal.pone.0239124 Text en © 2020 Buffault et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Buffault, Juliette Zéboulon, Pierre Liang, Hong Chiche, Anthony Luzu, Jade Robin, Mathieu Rabut, Ghislaine Labetoulle, Marc Labbé, Antoine Baudouin, Christophe Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
title | Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
title_full | Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
title_fullStr | Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
title_full_unstemmed | Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
title_short | Assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
title_sort | assessment of corneal epithelial thickness mapping in epithelial basement membrane dystrophy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688121/ https://www.ncbi.nlm.nih.gov/pubmed/33237913 http://dx.doi.org/10.1371/journal.pone.0239124 |
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