Detection of KRAS mutations in liquid biopsies from metastatic colorectal cancer patients using droplet digital PCR, Idylla, and next generation sequencing

Circulating tumor DNA (ctDNA) is released from cancer cells and oncogenic mutations in ctDNA can be measured from plasma samples. Droplet digital PCR (ddPCR) is a sensitive and specific method for the detection of mutations in ctDNA. We analyzed serial plasma samples (n = 80) from ten metastatic col...

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Detalles Bibliográficos
Autores principales: Holm, Matilda, Andersson, Emma, Osterlund, Emerik, Ovissi, Ali, Soveri, Leena-Maija, Anttonen, Anna-Kaisa, Kytölä, Soili, Aittomäki, Kristiina, Osterlund, Pia, Ristimäki, Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688175/
https://www.ncbi.nlm.nih.gov/pubmed/33237900
http://dx.doi.org/10.1371/journal.pone.0239819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688175/
https://www.ncbi.nlm.nih.gov/pubmed/33237900
http://dx.doi.org/10.1371/journal.pone.0239819

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