Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Allen, Chiou, Joshua, Poirion, Olivier B, Buchanan, Justin, Valdez, Michael J, Verheyden, Jamie M, Hou, Xiaomeng, Kudtarkar, Parul, Narendra, Sharvari, Newsome, Jacklyn M, Guo, Minzhe, Faddah, Dina A, Zhang, Kai, Young, Randee E, Barr, Justinn, Sajti, Eniko, Misra, Ravi, Huyck, Heidie, Rogers, Lisa, Poole, Cory, Whitsett, Jeffery A, Pryhuber, Gloria, Xu, Yan, Gaulton, Kyle J, Preissl, Sebastian, Sun, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688309/
https://www.ncbi.nlm.nih.gov/pubmed/33164753
http://dx.doi.org/10.7554/eLife.62522

Ejemplares similares

Ejemplares similares