Structural basis for SARM1 inhibition and activation under energetic stress

SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its activation under stress conditions are still unknown. Here, we present cryo-EM maps of SARM1 at 2.9 and 2.7 Å resolu...

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Detalles Bibliográficos
Autores principales: Sporny, Michael, Guez-Haddad, Julia, Khazma, Tami, Yaron, Avraham, Dessau, Moshe, Shkolnisky, Yoel, Mim, Carsten, Isupov, Michail N, Zalk, Ran, Hons, Michael, Opatowsky, Yarden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688312/
https://www.ncbi.nlm.nih.gov/pubmed/33185189
http://dx.doi.org/10.7554/eLife.62021

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