The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production

Frameshift mutations in CALR (calreticulin) are associated with essential thrombocythemia (ET), but the stages at and mechanisms by which mutant CALR drives transformation remain incompletely defined. Here, we use single-cell approaches to examine the hematopoietic stem/progenitor cell landscape in...

Descripción completa

Detalles Bibliográficos
Autores principales: Prins, Daniel, Park, Hyun Jung, Watcham, Sam, Li, Juan, Vacca, Michele, Bastos, Hugo P., Gerbaulet, Alexander, Vidal-Puig, Antonio, Göttgens, Berthold, Green, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688335/
https://www.ncbi.nlm.nih.gov/pubmed/33239297
http://dx.doi.org/10.1126/sciadv.abd3139

Ejemplares similares

Ejemplares similares