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Dutch trends in the use of potentially harmful medication during pregnancy

AIMS: Recent population‐based data on drug utilization around pregnancy are lacking. This study aims to examine the prevalence of drug exposure in the Netherlands during the preconception, pregnancy and postpartum periods, with special emphasis on trends of potentially harmful medication over the ye...

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Autores principales: Houben, Eline, te Winkel, Bernke, Steegers, Eric A. P., Herings, Ron M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688525/
https://www.ncbi.nlm.nih.gov/pubmed/32374086
http://dx.doi.org/10.1111/bcp.14341
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author Houben, Eline
te Winkel, Bernke
Steegers, Eric A. P.
Herings, Ron M. C.
author_facet Houben, Eline
te Winkel, Bernke
Steegers, Eric A. P.
Herings, Ron M. C.
author_sort Houben, Eline
collection PubMed
description AIMS: Recent population‐based data on drug utilization around pregnancy are lacking. This study aims to examine the prevalence of drug exposure in the Netherlands during the preconception, pregnancy and postpartum periods, with special emphasis on trends of potentially harmful medication over the years. METHODS: A population‐based study was conducted using records from the PHARMO Perinatal Research Network. From 1999 to 2017, the proportion of pregnancies during which women used any medication or potentially harmful medication was assessed, overall and stratified by timing of exposure relative to pregnancy and by the year of delivery. RESULTS: Overall, 357 226 (73%) and 166 484 (34%) of 487 122 selected pregnancies were exposed to any and potentially harmful medication, respectively. Among these 487 122 pregnancies, preconception prevalence for use of potentially harmful medication was 43%, 24% during the first trimester, 19% during the second, 16% during the third, and 45% postpartum. A declining trend was observed for exposure to any medication, from 84% in 1999 to 68% in 2017. No clear changes were observed over time for the proportion of pregnancies exposed to potentially harmful medication. CONCLUSIONS: Our study shows that the use of potentially harmful medication was high over the last two decades. Although there was a declining trend over the years in overall medication use, during a steady one‐third of pregnancies, women used potentially harmful medication. Our findings highlight the need for an increased sense of urgency among both healthcare providers and women of reproductive age regarding potential risks associated with pharmacological treatment during pregnancy.
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spelling pubmed-76885252020-12-09 Dutch trends in the use of potentially harmful medication during pregnancy Houben, Eline te Winkel, Bernke Steegers, Eric A. P. Herings, Ron M. C. Br J Clin Pharmacol Original Articles AIMS: Recent population‐based data on drug utilization around pregnancy are lacking. This study aims to examine the prevalence of drug exposure in the Netherlands during the preconception, pregnancy and postpartum periods, with special emphasis on trends of potentially harmful medication over the years. METHODS: A population‐based study was conducted using records from the PHARMO Perinatal Research Network. From 1999 to 2017, the proportion of pregnancies during which women used any medication or potentially harmful medication was assessed, overall and stratified by timing of exposure relative to pregnancy and by the year of delivery. RESULTS: Overall, 357 226 (73%) and 166 484 (34%) of 487 122 selected pregnancies were exposed to any and potentially harmful medication, respectively. Among these 487 122 pregnancies, preconception prevalence for use of potentially harmful medication was 43%, 24% during the first trimester, 19% during the second, 16% during the third, and 45% postpartum. A declining trend was observed for exposure to any medication, from 84% in 1999 to 68% in 2017. No clear changes were observed over time for the proportion of pregnancies exposed to potentially harmful medication. CONCLUSIONS: Our study shows that the use of potentially harmful medication was high over the last two decades. Although there was a declining trend over the years in overall medication use, during a steady one‐third of pregnancies, women used potentially harmful medication. Our findings highlight the need for an increased sense of urgency among both healthcare providers and women of reproductive age regarding potential risks associated with pharmacological treatment during pregnancy. John Wiley and Sons Inc. 2020-05-26 2020-12 /pmc/articles/PMC7688525/ /pubmed/32374086 http://dx.doi.org/10.1111/bcp.14341 Text en © 2020 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Houben, Eline
te Winkel, Bernke
Steegers, Eric A. P.
Herings, Ron M. C.
Dutch trends in the use of potentially harmful medication during pregnancy
title Dutch trends in the use of potentially harmful medication during pregnancy
title_full Dutch trends in the use of potentially harmful medication during pregnancy
title_fullStr Dutch trends in the use of potentially harmful medication during pregnancy
title_full_unstemmed Dutch trends in the use of potentially harmful medication during pregnancy
title_short Dutch trends in the use of potentially harmful medication during pregnancy
title_sort dutch trends in the use of potentially harmful medication during pregnancy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688525/
https://www.ncbi.nlm.nih.gov/pubmed/32374086
http://dx.doi.org/10.1111/bcp.14341
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