Cargando…

An epigenome-wide association study of metabolic syndrome and its components

The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate knowledge of the pathological mechanisms behind the condition at the methylation level, we conducted an epigenome-wide association study (EWAS) of M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nuotio, Marja-Liisa, Pervjakova, Natalia, Joensuu, Anni, Karhunen, Ville, Hiekkalinna, Tero, Milani, Lili, Kettunen, Johannes, Järvelin, Marjo-Riitta, Jousilahti, Pekka, Metspalu, Andres, Salomaa, Veikko, Kristiansson, Kati, Perola, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688654/ https://www.ncbi.nlm.nih.gov/pubmed/33239708 http://dx.doi.org/10.1038/s41598-020-77506-z

Ejemplares similares

Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
por: Mäkinen, Ville-Petteri, et al.
Publicado: (2023)

Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
por: Konttinen, Hanna, et al.
Publicado: (2015)

Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation
por: Tukiainen, Taru, et al.
Publicado: (2014)

Genetic fine-mapping from summary data using a nonlocal prior improves the detection of multiple causal variants
por: Karhunen, Ville, et al.
Publicado: (2023)

Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population
por: Salo, Perttu P., et al.
Publicado: (2015)

Common Genetic Variants Associated with Sudden Cardiac Death: The FinSCDgen Study
por: Lahtinen, Annukka M., et al.
Publicado: (2012)

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis
por: Inouye, Michael, et al.
Publicado: (2012)

Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis
por: Wang, Qin, et al.
Publicado: (2020)

Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure
por: Gaál, Emília Ilona, et al.
Publicado: (2012)

Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events
por: Auro, Kirsi, et al.
Publicado: (2007)

Gender Differences in Genetic Risk Profiles for Cardiovascular Disease
por: Silander, Kaisa, et al.
Publicado: (2008)

Genetic and observational evidence: No independent role for cholesterol efflux over static high‐density lipoprotein concentration measures in coronary heart disease risk assessment
por: Kuusisto, Sanna, et al.
Publicado: (2022)

A distinctive DNA methylation pattern in insufficient sleep
por: Lahtinen, Alexandra, et al.
Publicado: (2019)

Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank
por: Julkunen, Heli, et al.
Publicado: (2023)

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
por: Wang, Qin, et al.
Publicado: (2016)

The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations
por: Karhunen, Ville, et al.
Publicado: (2021)

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design
por: Nuotio, Marja-Liisa, et al.
Publicado: (2022)

MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies
por: Haller, Toomas, et al.
Publicado: (2017)

Cross-sectionally Calculated Metabolic Aging Does Not Relate to Longitudinal Metabolic Changes—Support for Stratified Aging Models
por: Ala-Korpela, Mika, et al.
Publicado: (2023)

Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome
por: Parkkonen, Olavi, et al.
Publicado: (2017)

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts
por: Ahola-Olli, Ari V., et al.
Publicado: (2019)

There is always glucose in normal urine: unspecific excretion associated with serum glucose and glomerular filtration rate
por: Li, Tianqi, et al.
Publicado: (2022)

An Immune Response Network Associated with Blood Lipid Levels
por: Inouye, Michael, et al.
Publicado: (2010)

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population
por: Salo, Perttu P., et al.
Publicado: (2017)

Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease: Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts
por: Tikkanen, Emmi, et al.
Publicado: (2021)

Risks of Overweight and Abdominal Obesity at Age 16 Years Associated With Prenatal Exposures to Maternal Prepregnancy Overweight and Gestational Diabetes Mellitus
por: Pirkola, Jatta, et al.
Publicado: (2010)

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study
por: Marjonen, Heidi, et al.
Publicado: (2021)

Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression
por: Marttinen, Pekka, et al.
Publicado: (2014)

Changes in the fine-scale genetic structure of Finland through the 20(th) century
por: Kerminen, Sini, et al.
Publicado: (2021)

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
por: Sliz, Eeva, et al.
Publicado: (2019)

24-h urinary sodium excretion and the risk of adverse outcomes
por: Vuori, Matti A., et al.
Publicado: (2020)

metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis
por: Cichonska, Anna, et al.
Publicado: (2016)

Serum lipopolysaccharides predict advanced liver disease in the general population
por: Männistö, Ville, et al.
Publicado: (2019)

Physical activity associates with subarachnoid hemorrhage risk– a population-based long-term cohort study
por: Lindbohm, Joni V., et al.
Publicado: (2019)

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome
por: Canouil, Mickaël, et al.
Publicado: (2021)

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
por: Nath, Artika P., et al.
Publicado: (2017)

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
por: Wang, Qin, et al.
Publicado: (2016)

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study
por: Wang, Qin, et al.
Publicado: (2019)

Bayesian Variable Selection in Searching for Additive and Dominant Effects in Genome-Wide Data
por: Peltola, Tomi, et al.
Publicado: (2012)

Association of LIN28B with Adult Adiposity-Related Traits in Females
por: Leinonen, Jaakko T., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_o2bkhcap6j7e3ed2blnhn7bci4