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Bacteriophages of Helicobacter pylori
The bacterium Helicobacter pylori colonize the stomach in approximately half of the world’s population. Infection with this bacterium is associated with gastritis, peptic ulcer, adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Besides being a pathogen with worldwide prevalence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688985/ https://www.ncbi.nlm.nih.gov/pubmed/33281754 http://dx.doi.org/10.3389/fmicb.2020.549084 |
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author | Muñoz, Angela B. Stepanian, Johanna Trespalacios, Alba Alicia Vale, Filipa F. |
author_facet | Muñoz, Angela B. Stepanian, Johanna Trespalacios, Alba Alicia Vale, Filipa F. |
author_sort | Muñoz, Angela B. |
collection | PubMed |
description | The bacterium Helicobacter pylori colonize the stomach in approximately half of the world’s population. Infection with this bacterium is associated with gastritis, peptic ulcer, adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Besides being a pathogen with worldwide prevalence, H. pylori show increasingly high antibiotic resistance rates, making the development of new therapeutic strategies against this bacterium challenging. Furthermore, H. pylori is a genetically diverse bacterium, which may be influenced by the presence of mobile genomic elements, including prophages. In this review, we analyze these issues and summarize various reports and findings related to phages and H. pylori, discussing the relationship between the presence of these elements and the genomic diversity, virulence, and fitness of this bacterium. We also analyze the state of the knowledge on the potential utility of bacteriophages as a therapeutic strategy for H. pylori. |
format | Online Article Text |
id | pubmed-7688985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76889852020-12-03 Bacteriophages of Helicobacter pylori Muñoz, Angela B. Stepanian, Johanna Trespalacios, Alba Alicia Vale, Filipa F. Front Microbiol Microbiology The bacterium Helicobacter pylori colonize the stomach in approximately half of the world’s population. Infection with this bacterium is associated with gastritis, peptic ulcer, adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Besides being a pathogen with worldwide prevalence, H. pylori show increasingly high antibiotic resistance rates, making the development of new therapeutic strategies against this bacterium challenging. Furthermore, H. pylori is a genetically diverse bacterium, which may be influenced by the presence of mobile genomic elements, including prophages. In this review, we analyze these issues and summarize various reports and findings related to phages and H. pylori, discussing the relationship between the presence of these elements and the genomic diversity, virulence, and fitness of this bacterium. We also analyze the state of the knowledge on the potential utility of bacteriophages as a therapeutic strategy for H. pylori. Frontiers Media S.A. 2020-11-12 /pmc/articles/PMC7688985/ /pubmed/33281754 http://dx.doi.org/10.3389/fmicb.2020.549084 Text en Copyright © 2020 Muñoz, Stepanian, Trespalacios and Vale. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Muñoz, Angela B. Stepanian, Johanna Trespalacios, Alba Alicia Vale, Filipa F. Bacteriophages of Helicobacter pylori |
title | Bacteriophages of Helicobacter pylori |
title_full | Bacteriophages of Helicobacter pylori |
title_fullStr | Bacteriophages of Helicobacter pylori |
title_full_unstemmed | Bacteriophages of Helicobacter pylori |
title_short | Bacteriophages of Helicobacter pylori |
title_sort | bacteriophages of helicobacter pylori |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688985/ https://www.ncbi.nlm.nih.gov/pubmed/33281754 http://dx.doi.org/10.3389/fmicb.2020.549084 |
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