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Tumor-Specific Antibody, Cetuximab, Enhances the In Situ Vaccine Effect of Radiation in Immunologically Cold Head and Neck Squamous Cell Carcinoma
In head and neck squamous cell carcinoma (HNSCC) tumors that over-expresses huEGFR, the anti-EGFR antibody, cetuximab, antagonizes tumor cell viability and sensitizes to radiation therapy. However, the immunologic interactions between cetuximab and radiation therapy are not well understood. We trans...
Autores principales: | Jin, Won Jong, Erbe, Amy K., Schwarz, Ciara N., Jaquish, Abigail A., Anderson, Bryce R., Sriramaneni, Raghava N., Jagodinsky, Justin C., Bates, Amber M., Clark, Paul A., Le, Trang, Lan, Keng-Hsueh, Chen, Yi, Kim, KyungMann, Morris, Zachary S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689006/ https://www.ncbi.nlm.nih.gov/pubmed/33281820 http://dx.doi.org/10.3389/fimmu.2020.591139 |
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