Cargando…

Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model

Heterogeneity of gene expression and rarity of replication hamper molecular analysis of β-cell mass restoration in adult pancreas. Here, we show transcriptional dynamics in β-cell replication process by single-cell RNA sequencing of murine pancreas with or without partial pancreatectomy. We observed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tatsuoka, Hisato, Sakamoto, Satoko, Yabe, Daisuke, Kabai, Ryotaro, Kato, Unyanee, Okumura, Tatsuya, Botagarova, Ainur, Tokumoto, Shinsuke, Usui, Ryota, Ogura, Masahito, Nagashima, Kazuaki, Mukai, Eri, Fujitani, Yoshio, Watanabe, Akira, Inagaki, Nobuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689163/ https://www.ncbi.nlm.nih.gov/pubmed/33294783 http://dx.doi.org/10.1016/j.isci.2020.101774

Ejemplares similares

Generation and Characterization of a Novel Mouse Model That Allows Spatiotemporal Quantification of Pancreatic β-Cell Proliferation
por: Tokumoto, Shinsuke, et al.
Publicado: (2020)

GPR40 activation initiates store-operated Ca(2+) entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells
por: Usui, Ryota, et al.
Publicado: (2019)

Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β‐cells
por: Sato, Hiroki, et al.
Publicado: (2015)

An analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3-D imaging
por: Hatoko, Tomonobu, et al.
Publicado: (2022)

Preservation effect of imeglimin on pancreatic β-cell mass: Noninvasive evaluation using (111)In-exendin-4 SPECT/CT imaging and the perspective of mitochondrial involvements
por: Fauzi, Muhammad, et al.
Publicado: (2022)

Palmitate induces reactive oxygen species production and β‐cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling
por: Sato, Yuichi, et al.
Publicado: (2014)

Insulinoma with a History of Epilepsy: Still a Possible Misleading Factor in the Early Diagnosis of Insulinoma
por: Murakami, Takaaki, et al.
Publicado: (2017)

Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction
por: Sasaki, Mayumi, et al.
Publicado: (2013)

Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes patients: The association between remaining β‐cell function and the achievement of the glycated hemoglobin target 1 year after initiation
por: Usui, Ryota, et al.
Publicado: (2017)

Reply to the comment of Wilbrink et al. on Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β‐cell function and the achievement of the HbA1c target 1 year after initiation
por: Usui, Ryota, et al.
Publicado: (2018)

Relationship between deterioration of glycated hemoglobin‐lowering effects in dipeptidyl peptidase‐4 inhibitor monotherapy and dietary habits: Retrospective analysis of Japanese individuals with type 2 diabetes
por: Kuwata, Hitoshi, et al.
Publicado: (2017)

Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic β-Cells
por: Mukai, Eri, et al.
Publicado: (2022)

Initiating SGLT2 inhibitor therapy to improve renal outcomes for persons with diabetes eligible for an intensified glucose-lowering regimen: hypothetical intervention using parametric g-formula modeling
por: Takeuchi, Masato, et al.
Publicado: (2022)

Bullous pemphigoid associated with dipeptidyl peptidase‐4 inhibitors: A report of five cases
por: Yoshiji, Satoshi, et al.
Publicado: (2017)

Psychological Factors Motivating Male Japanese Workers With Type 2 Diabetes to Engage in Dietary Modifications: A Qualitative Descriptive Study
por: Morinishi, Kanako, et al.
Publicado: (2023)

A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5)
por: Fujita, Yuki, et al.
Publicado: (2020)

Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy
por: Niwano, Fumimaru, et al.
Publicado: (2021)

Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion
por: Wang, Yu, et al.
Publicado: (2017)

Circadian rhythms and diabetes
por: Kurose, Takeshi, et al.
Publicado: (2011)

Bullous pemphigoid with dipeptidyl peptidase‐4 inhibitors: Clinical features and pathophysiology
por: Murakami, Takaaki, et al.
Publicado: (2019)

Unmet needs in current clinical practice for insulinoma: Lessons from nationwide studies in Japan
por: Murakami, Takaaki, et al.
Publicado: (2021)

Development of a preoperative prediction model for new-onset diabetes mellitus after partial pancreatectomy: A retrospective cohort study
por: Yamamoto-Kataoka, Sachiko, et al.
Publicado: (2021)

Voxel‐based specific regional analysis system for Alzheimer’s disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study
por: Ueba, Yoko, et al.
Publicado: (2021)

Clinical Practice Changes After Post-Market Safety Reports on Desmopressin Orally Disintegrating Tablet in Japan: A Single-Center Retrospective Study
por: Yasuda, Takuma, et al.
Publicado: (2021)

Year‐long effects of COVID‐19 restrictions on glycemic control and body composition in patients with glucose intolerance in Japan: A single‐center retrospective study
por: Tsukaguchi, Ryo, et al.
Publicado: (2022)

Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases
por: Hatoko, Tomonobu, et al.
Publicado: (2020)

Current understanding of imeglimin action on pancreatic β‐cells: Involvement of mitochondria and endoplasmic reticulum homeostasis
por: Fauzi, Muhammad, et al.
Publicado: (2022)

Laparoscopic distal pancreatectomy for pancreatic arteriovenous malformation complicated with portal hypertension
por: Abiko, Takehiro, et al.
Publicado: (2021)

Long‐term outcome of islet transplantation on insulin‐dependent diabetes mellitus: An observational cohort study
por: Nakamura, Toshihiro, et al.
Publicado: (2019)

A unique profile of insulin antibody titer in islet‐transplanted patients
por: Keidai, Yamato, et al.
Publicado: (2022)

Robotic pancreatectomies
por: Ramera, Marco, et al.
Publicado: (2016)

Ceritinib‐associated hyperglycemia in the Japanese Adverse Drug Event Report Database
por: Fujita, Haruka, et al.
Publicado: (2019)

Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity
por: Usui, Ryota, et al.
Publicado: (2019)

Reduced glycemic variability and flexible graft function after islet transplantation: A case report
por: Nakamura, Toshihiro, et al.
Publicado: (2020)

Beta‐cell replacement strategies for diabetes
por: Kieffer, Timothy J, et al.
Publicado: (2017)

Laparoscopic Distal Pancreatectomy
por: Sherwinter, Danny A, et al.
Publicado: (2012)

Robotic Distal Pancreatectomy
por: Suman, Paritosh, et al.
Publicado: (2013)

Pancreatectomy and Pancreatic Surgery
por: Jabłońska, Beata, et al.
Publicado: (2023)

B1 SOX Coordinate Cell Specification with Patterning and Morphogenesis in the Early Zebrafish Embryo
por: Okuda, Yuichi, et al.
Publicado: (2010)

Prediction of RNA secondary structure with pseudoknots using integer programming
por: Poolsap, Unyanee, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_kbdrof9hqdim9metjjnq7a5fqp