Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters

The combination of large volume injection and mixed-mode chromatography was performed for direct ultra-trace LC-MS/MS analysis of seven artificial sweeteners with varying physicochemical properties in surface water samples. • The injection volume was raised from 10 µL to 500 µL, while the overall an...

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Detalles Bibliográficos
Autores principales: Henschel, Jonas, Hayen, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689179/
https://www.ncbi.nlm.nih.gov/pubmed/33294396
http://dx.doi.org/10.1016/j.mex.2020.101134
Descripción
Sumario:The combination of large volume injection and mixed-mode chromatography was performed for direct ultra-trace LC-MS/MS analysis of seven artificial sweeteners with varying physicochemical properties in surface water samples. • The injection volume was raised from 10 µL to 500 µL, while the overall analysis time was only increased by ≈5 min compared to the initial method. • Online column head refocusing and concentration of analytes enabled detection in sub-ng L(−1) concentration range without elaborate sample preparation steps. • Relative standard deviations <7% despite multiple injection into the loop.

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