Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters

The combination of large volume injection and mixed-mode chromatography was performed for direct ultra-trace LC-MS/MS analysis of seven artificial sweeteners with varying physicochemical properties in surface water samples. • The injection volume was raised from 10 µL to 500 µL, while the overall an...

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Detalles Bibliográficos
Autores principales: Henschel, Jonas, Hayen, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689179/
https://www.ncbi.nlm.nih.gov/pubmed/33294396
http://dx.doi.org/10.1016/j.mex.2020.101134
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author Henschel, Jonas
Hayen, Heiko
author_facet Henschel, Jonas
Hayen, Heiko
author_sort Henschel, Jonas
collection PubMed
description The combination of large volume injection and mixed-mode chromatography was performed for direct ultra-trace LC-MS/MS analysis of seven artificial sweeteners with varying physicochemical properties in surface water samples. • The injection volume was raised from 10 µL to 500 µL, while the overall analysis time was only increased by ≈5 min compared to the initial method. • Online column head refocusing and concentration of analytes enabled detection in sub-ng L(−1) concentration range without elaborate sample preparation steps. • Relative standard deviations <7% despite multiple injection into the loop.
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spelling pubmed-76891792020-12-07 Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters Henschel, Jonas Hayen, Heiko MethodsX Method Article The combination of large volume injection and mixed-mode chromatography was performed for direct ultra-trace LC-MS/MS analysis of seven artificial sweeteners with varying physicochemical properties in surface water samples. • The injection volume was raised from 10 µL to 500 µL, while the overall analysis time was only increased by ≈5 min compared to the initial method. • Online column head refocusing and concentration of analytes enabled detection in sub-ng L(−1) concentration range without elaborate sample preparation steps. • Relative standard deviations <7% despite multiple injection into the loop. Elsevier 2020-11-07 /pmc/articles/PMC7689179/ /pubmed/33294396 http://dx.doi.org/10.1016/j.mex.2020.101134 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Method Article
Henschel, Jonas
Hayen, Heiko
Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
title Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
title_full Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
title_fullStr Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
title_full_unstemmed Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
title_short Application of large volume injection for sensitive LC-MS/MS analysis of seven artificial sweeteners in surface waters
title_sort application of large volume injection for sensitive lc-ms/ms analysis of seven artificial sweeteners in surface waters
topic Method Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689179/
https://www.ncbi.nlm.nih.gov/pubmed/33294396
http://dx.doi.org/10.1016/j.mex.2020.101134
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