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Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas
Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonst...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689243/ https://www.ncbi.nlm.nih.gov/pubmed/33250680 http://dx.doi.org/10.17179/excli2020-2762 |
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author | Sajed, Roya Saeednejad Zanjani, Leili Rahimi, Mandana Mansoori, Maryam Zarnani, Amir-Hassan Madjd, Zahra Ghods, Roya |
author_facet | Sajed, Roya Saeednejad Zanjani, Leili Rahimi, Mandana Mansoori, Maryam Zarnani, Amir-Hassan Madjd, Zahra Ghods, Roya |
author_sort | Sajed, Roya |
collection | PubMed |
description | Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the development of several cancers such as prostate, pancreas, and bladder. However, its clinical significance in breast cancer is unclear yet. In the present study, the membranous, cytoplasmic, and nuclear expression levels of dynamin 2 molecule were evaluated for the first time, using immunohistochemistry (IHC) on tissue microarray (TMA) slides in 113 invasive breast cancer tissues. Moreover, afterward, the association between the dynamin 2 expression and clinicopathological features was determined. Our finding showed that, a higher nuclear expression of dynamin 2 is significantly associated with an increase in tumor stage (P = 0.05), histological grade (P = 0.001), and age of the patients (P = 0.03). In addition, analysis of the cytoplasmic expression levels of this molecule revealed that, there was a statistically significant difference between the expression levels of dynamin 2 among the different breast cancer subtypes (P = 0.003). Moreover, a significant association was found between the increased expression of dynamin 2 membranous and vascular invasion (VI) (P = 0.02). We showed that dynamin 2 protein expression has an association with more aggressive tumor behavior and more advanced disease in the patients with breast cancer; therefore, dynamin 2 molecule could be considered as an indicator of disease progression and aggressiveness. |
format | Online Article Text |
id | pubmed-7689243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-76892432020-11-27 Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas Sajed, Roya Saeednejad Zanjani, Leili Rahimi, Mandana Mansoori, Maryam Zarnani, Amir-Hassan Madjd, Zahra Ghods, Roya EXCLI J Original Article Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the development of several cancers such as prostate, pancreas, and bladder. However, its clinical significance in breast cancer is unclear yet. In the present study, the membranous, cytoplasmic, and nuclear expression levels of dynamin 2 molecule were evaluated for the first time, using immunohistochemistry (IHC) on tissue microarray (TMA) slides in 113 invasive breast cancer tissues. Moreover, afterward, the association between the dynamin 2 expression and clinicopathological features was determined. Our finding showed that, a higher nuclear expression of dynamin 2 is significantly associated with an increase in tumor stage (P = 0.05), histological grade (P = 0.001), and age of the patients (P = 0.03). In addition, analysis of the cytoplasmic expression levels of this molecule revealed that, there was a statistically significant difference between the expression levels of dynamin 2 among the different breast cancer subtypes (P = 0.003). Moreover, a significant association was found between the increased expression of dynamin 2 membranous and vascular invasion (VI) (P = 0.02). We showed that dynamin 2 protein expression has an association with more aggressive tumor behavior and more advanced disease in the patients with breast cancer; therefore, dynamin 2 molecule could be considered as an indicator of disease progression and aggressiveness. Leibniz Research Centre for Working Environment and Human Factors 2020-10-29 /pmc/articles/PMC7689243/ /pubmed/33250680 http://dx.doi.org/10.17179/excli2020-2762 Text en Copyright © 2020 Sajed et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Sajed, Roya Saeednejad Zanjani, Leili Rahimi, Mandana Mansoori, Maryam Zarnani, Amir-Hassan Madjd, Zahra Ghods, Roya Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
title | Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
title_full | Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
title_fullStr | Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
title_full_unstemmed | Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
title_short | Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
title_sort | overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689243/ https://www.ncbi.nlm.nih.gov/pubmed/33250680 http://dx.doi.org/10.17179/excli2020-2762 |
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