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Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology

Many similar characteristics in human and dog cancers including, spontaneous development, clinical presentation, tumor heterogeneity, disease progression, and response to standard therapies have promoted the approval of this comparative model as an alternative to mice. Breast cancer represents the s...

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Autores principales: Amirkhani Namagerdi, Asadoor, d’Angelo, Danila, Ciani, Francesca, Iannuzzi, Carmelina Antonella, Napolitano, Francesco, Avallone, Luigi, De Laurentiis, Michelino, Giordano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689249/
https://www.ncbi.nlm.nih.gov/pubmed/33282730
http://dx.doi.org/10.3389/fonc.2020.563779
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author Amirkhani Namagerdi, Asadoor
d’Angelo, Danila
Ciani, Francesca
Iannuzzi, Carmelina Antonella
Napolitano, Francesco
Avallone, Luigi
De Laurentiis, Michelino
Giordano, Antonio
author_facet Amirkhani Namagerdi, Asadoor
d’Angelo, Danila
Ciani, Francesca
Iannuzzi, Carmelina Antonella
Napolitano, Francesco
Avallone, Luigi
De Laurentiis, Michelino
Giordano, Antonio
author_sort Amirkhani Namagerdi, Asadoor
collection PubMed
description Many similar characteristics in human and dog cancers including, spontaneous development, clinical presentation, tumor heterogeneity, disease progression, and response to standard therapies have promoted the approval of this comparative model as an alternative to mice. Breast cancer represents the second most frequent neoplasm in humans after lung cancer. Triple-negative breast cancers (TNBC) constitute around 15% of all cases of breast cancer and do not express estrogen receptor (ER), progesterone receptor (PR), and do not overexpress human epidermal growth factor receptor 2 (HER2). As a result, they do not benefit from hormonal or trastuzumab-based therapy. Patients with TNBC have worse overall survival than patients with non-TNBC. Lehmann and collaborators described six different molecular subtypes of TNBC which further demonstrated its transcriptional heterogeneity. This six TNBC subtype classification has therapeutic implications. Breast cancer is the second most frequent neoplasm in sexually intact female dogs after skin cancer. Canine mammary tumors are a naturally occurring heterogeneous group of cancers that have several features in common with human breast cancer (HBC). These similarities include etiology, signaling pathway activation, and histological classification. Molecularly CMTs are more like TNBCs, and therefore dogs are powerful spontaneous models of cancer to test new therapeutic approaches, particularly for human TNBCs. More malignant tumors of the breast are more often ER and PR negative in both humans and dogs. Promising breast cancer biomarkers in both humans and canines are cancer-associated stroma (CAS), circulating tumor cells and tumor DNA (ctDNA), exosomes and miRNAs, and metabolites.
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spelling pubmed-76892492020-12-04 Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology Amirkhani Namagerdi, Asadoor d’Angelo, Danila Ciani, Francesca Iannuzzi, Carmelina Antonella Napolitano, Francesco Avallone, Luigi De Laurentiis, Michelino Giordano, Antonio Front Oncol Oncology Many similar characteristics in human and dog cancers including, spontaneous development, clinical presentation, tumor heterogeneity, disease progression, and response to standard therapies have promoted the approval of this comparative model as an alternative to mice. Breast cancer represents the second most frequent neoplasm in humans after lung cancer. Triple-negative breast cancers (TNBC) constitute around 15% of all cases of breast cancer and do not express estrogen receptor (ER), progesterone receptor (PR), and do not overexpress human epidermal growth factor receptor 2 (HER2). As a result, they do not benefit from hormonal or trastuzumab-based therapy. Patients with TNBC have worse overall survival than patients with non-TNBC. Lehmann and collaborators described six different molecular subtypes of TNBC which further demonstrated its transcriptional heterogeneity. This six TNBC subtype classification has therapeutic implications. Breast cancer is the second most frequent neoplasm in sexually intact female dogs after skin cancer. Canine mammary tumors are a naturally occurring heterogeneous group of cancers that have several features in common with human breast cancer (HBC). These similarities include etiology, signaling pathway activation, and histological classification. Molecularly CMTs are more like TNBCs, and therefore dogs are powerful spontaneous models of cancer to test new therapeutic approaches, particularly for human TNBCs. More malignant tumors of the breast are more often ER and PR negative in both humans and dogs. Promising breast cancer biomarkers in both humans and canines are cancer-associated stroma (CAS), circulating tumor cells and tumor DNA (ctDNA), exosomes and miRNAs, and metabolites. Frontiers Media S.A. 2020-11-12 /pmc/articles/PMC7689249/ /pubmed/33282730 http://dx.doi.org/10.3389/fonc.2020.563779 Text en Copyright © 2020 Amirkhani Namagerdi, d’Angelo, Ciani, Iannuzzi, Napolitano, Avallone, De Laurentiis and Giordano http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Amirkhani Namagerdi, Asadoor
d’Angelo, Danila
Ciani, Francesca
Iannuzzi, Carmelina Antonella
Napolitano, Francesco
Avallone, Luigi
De Laurentiis, Michelino
Giordano, Antonio
Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology
title Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology
title_full Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology
title_fullStr Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology
title_full_unstemmed Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology
title_short Triple-Negative Breast Cancer Comparison With Canine Mammary Tumors From Light Microscopy to Molecular Pathology
title_sort triple-negative breast cancer comparison with canine mammary tumors from light microscopy to molecular pathology
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689249/
https://www.ncbi.nlm.nih.gov/pubmed/33282730
http://dx.doi.org/10.3389/fonc.2020.563779
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