Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is needed for understanding skewed immune responses and defining predictors of outcome. Here, we performed a longitudinal multi-omics study using a two-center cohort of 14 patients. We analyzed the bulk tra...

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Autores principales: Bernardes, Joana P., Mishra, Neha, Tran, Florian, Bahmer, Thomas, Best, Lena, Blase, Johanna I., Bordoni, Dora, Franzenburg, Jeanette, Geisen, Ulf, Josephs-Spaulding, Jonathan, Köhler, Philipp, Künstner, Axel, Rosati, Elisa, Aschenbrenner, Anna C., Bacher, Petra, Baran, Nathan, Boysen, Teide, Brandt, Burkhard, Bruse, Niklas, Dörr, Jonathan, Dräger, Andreas, Elke, Gunnar, Ellinghaus, David, Fischer, Julia, Forster, Michael, Franke, Andre, Franzenburg, Sören, Frey, Norbert, Friedrichs, Anette, Fuß, Janina, Glück, Andreas, Hamm, Jacob, Hinrichsen, Finn, Hoeppner, Marc P., Imm, Simon, Junker, Ralf, Kaiser, Sina, Kan, Ying H., Knoll, Rainer, Lange, Christoph, Laue, Georg, Lier, Clemens, Lindner, Matthias, Marinos, Georgios, Markewitz, Robert, Nattermann, Jacob, Noth, Rainer, Pickkers, Peter, Rabe, Klaus F., Renz, Alina, Röcken, Christoph, Rupp, Jan, Schaffarzyk, Annika, Scheffold, Alexander, Schulte-Schrepping, Jonas, Schunk, Domagoj, Skowasch, Dirk, Ulas, Thomas, Wandinger, Klaus-Peter, Wittig, Michael, Zimmermann, Johannes, Busch, Hauke, Hoyer, Bimba F., Kaleta, Christoph, Heyckendorf, Jan, Kox, Matthijs, Rybniker, Jan, Schreiber, Stefan, Schultze, Joachim L., Rosenstiel, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689306/
https://www.ncbi.nlm.nih.gov/pubmed/33296687
http://dx.doi.org/10.1016/j.immuni.2020.11.017

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