Low-Avidity CD4(+) T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19

CD4(+) T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection. Here, we utilized SARS-CoV-2-reactive CD4(+) T cell enrichment to examine the antigen avidity and clonality of these cells, as...

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Detalles Bibliográficos
Autores principales: Bacher, Petra, Rosati, Elisa, Esser, Daniela, Martini, Gabriela Rios, Saggau, Carina, Schiminsky, Esther, Dargvainiene, Justina, Schröder, Ina, Wieters, Imke, Khodamoradi, Yascha, Eberhardt, Fabian, Vehreschild, Maria J.G.T., Neb, Holger, Sonntagbauer, Michael, Conrad, Claudio, Tran, Florian, Rosenstiel, Philip, Markewitz, Robert, Wandinger, Klaus-Peter, Augustin, Max, Rybniker, Jan, Kochanek, Matthias, Leypoldt, Frank, Cornely, Oliver A., Koehler, Philipp, Franke, Andre, Scheffold, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689350/
https://www.ncbi.nlm.nih.gov/pubmed/33296686
http://dx.doi.org/10.1016/j.immuni.2020.11.016

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