Cargando…

Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

The repeated failures of amyloid-targeting therapies have challenged our narrow understanding of Alzheimer’s disease (AD) pathogenesis and inspired wide-ranging investigations into the underlying mechanisms of disease. Increasing evidence indicates that AD develops from an intricate web of biochemic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rayaprolu, Sruti, Higginbotham, Lenora, Bagchi, Pritha, Watson, Caroline M., Zhang, Tian, Levey, Allan I., Rangaraju, Srikant, Seyfried, Nicholas T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Neuropsychopharmacology Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689445/ https://www.ncbi.nlm.nih.gov/pubmed/32898852 http://dx.doi.org/10.1038/s41386-020-00840-3

Ejemplares similares

Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain
por: Rayaprolu, Sruti, et al.
Publicado: (2022)

Cellular Proteomic Profiling Using Proximity Labeling by TurboID-NES in Microglial and Neuronal Cell Lines
por: Sunna, Sydney, et al.
Publicado: (2023)

Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles
por: Santiago, Juliet V., et al.
Publicado: (2023)

Role of Inflammation in Suicide: From Mechanisms to Treatment
por: Brundin, Lena, et al.
Publicado: (2017)

Genetic Contributions of Inflammation to Depression
por: Barnes, Jacob, et al.
Publicado: (2017)

Pathogen–Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance
por: Raison, Charles L, et al.
Publicado: (2017)

US Epidemiology of Cannabis Use and Associated Problems
por: Hasin, Deborah S
Publicado: (2018)

CB(1) Receptor Signaling in the Brain: Extracting Specificity from Ubiquity
por: Busquets-Garcia, Arnau, et al.
Publicado: (2018)

Digital health data-driven approaches to understand human behavior
por: Marsch, Lisa A.
Publicado: (2020)

The ABCD study: understanding the development of risk for mental and physical health outcomes
por: Karcher, Nicole R., et al.
Publicado: (2020)

Sleep in the United States Military
por: Good, Cameron H., et al.
Publicado: (2019)

Deep learning for small and big data in psychiatry
por: Koppe, Georgia, et al.
Publicado: (2020)

Modeling brain, symptom, and behavior in the winds of change
por: Lydon-Staley, David M., et al.
Publicado: (2020)

Interpretation of psychiatric genome-wide association studies with multispecies heterogeneous functional genomic data integration
por: Reynolds, Timothy, et al.
Publicado: (2020)

Big behavior: challenges and opportunities in a new era of deep behavior profiling
por: von Ziegler, Lukas, et al.
Publicado: (2020)

Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders
por: Searles Quick, Veronica B., et al.
Publicado: (2020)

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease
por: Rayaprolu, Sruti, et al.
Publicado: (2020)

Biophysical K(v)3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s
por: Olah, Viktor J, et al.
Publicado: (2022)

Brain Cell Type-Specific Nuclear Proteomics Is Imperative to Resolve Neurodegenerative Disease Mechanisms
por: Nelson, Ruth S., et al.
Publicado: (2022)

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
por: Higginbotham, Lenora, et al.
Publicado: (2019)

Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer’s disease
por: Wang, Erming, et al.
Publicado: (2023)

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
por: Higginbotham, Lenora, et al.
Publicado: (2020)

The neurobiological basis of sex differences in learned fear and its inhibition
por: Day, Harriet L. L., et al.
Publicado: (2019)

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
por: Ping, Lingyan, et al.
Publicado: (2018)

Differential Phagocytic Properties of CD45(low) Microglia and CD45(high) Brain Mononuclear Phagocytes—Activation and Age-Related Effects
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
por: Ping, Lingyan, et al.
Publicado: (2020)

Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
por: Zlatic, Stephanie A., et al.
Publicado: (2022)

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease
por: Donovan, Laura E, et al.
Publicado: (2013)

Correction to: Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer’s disease
por: Donovan, Laura E., et al.
Publicado: (2021)

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain
por: Umoh, Mfon E, et al.
Publicado: (2017)

Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer’s Disease to Brain Ischemia
por: Pluta, Ryszard, et al.
Publicado: (2020)

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
por: Zhang, Zhentao, et al.
Publicado: (2015)

Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease
por: Modeste, Erica S., et al.
Publicado: (2023)

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease
por: Zhang, Zhentao, et al.
Publicado: (2014)

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease
por: Dai, Jingting, et al.
Publicado: (2018)

Proteomics of protein post-translational modifications implicated in neurodegeneration
por: Ren, Ru-Jing, et al.
Publicado: (2014)

Sleep in Alzheimer's Disease–Beyond Amyloid
por: Holth, Jerrah K., et al.
Publicado: (2016)

Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
por: Goettemoeller, Annie M, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u79l5sli897bnb93cmqq97nnnn