Integrative genomic meta-analysis reveals novel molecular insights into cystic fibrosis and ΔF508-CFTR rescue

Cystic fibrosis (CF), caused by mutations to CFTR, leads to severe and progressive lung disease. The most common mutant, ΔF508-CFTR, undergoes proteasomal degradation, extinguishing its anion channel function. Numerous in vitro interventions have been identified to partially rescue ΔF508-CFTR functi...

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Detalles Bibliográficos
Autores principales: Hodos, Rachel A., Strub, Matthew D., Ramachandran, Shyam, Li, Li, McCray, Paul B., Dudley, Joel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689470/
https://www.ncbi.nlm.nih.gov/pubmed/33239626
http://dx.doi.org/10.1038/s41598-020-76347-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689470/
https://www.ncbi.nlm.nih.gov/pubmed/33239626
http://dx.doi.org/10.1038/s41598-020-76347-0

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