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Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project

The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and...

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Autores principales: O’Sullivan, Dylan E., Metcalfe, Amy, Hillier, Troy W. R., King, Will D., Lee, Sangmin, Pader, Joy, Brenner, Darren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689485/
https://www.ncbi.nlm.nih.gov/pubmed/33239697
http://dx.doi.org/10.1038/s41598-020-76294-w
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author O’Sullivan, Dylan E.
Metcalfe, Amy
Hillier, Troy W. R.
King, Will D.
Lee, Sangmin
Pader, Joy
Brenner, Darren R.
author_facet O’Sullivan, Dylan E.
Metcalfe, Amy
Hillier, Troy W. R.
King, Will D.
Lee, Sangmin
Pader, Joy
Brenner, Darren R.
author_sort O’Sullivan, Dylan E.
collection PubMed
description The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level.
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spelling pubmed-76894852020-11-27 Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project O’Sullivan, Dylan E. Metcalfe, Amy Hillier, Troy W. R. King, Will D. Lee, Sangmin Pader, Joy Brenner, Darren R. Sci Rep Article The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level. Nature Publishing Group UK 2020-11-25 /pmc/articles/PMC7689485/ /pubmed/33239697 http://dx.doi.org/10.1038/s41598-020-76294-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
O’Sullivan, Dylan E.
Metcalfe, Amy
Hillier, Troy W. R.
King, Will D.
Lee, Sangmin
Pader, Joy
Brenner, Darren R.
Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_full Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_fullStr Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_full_unstemmed Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_short Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
title_sort combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in alberta’s tomorrow project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689485/
https://www.ncbi.nlm.nih.gov/pubmed/33239697
http://dx.doi.org/10.1038/s41598-020-76294-w
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