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Sleep quality among individuals with ketamine use and the mediating role of craving
Sleep problems are common in Taiwan. Poor sleep may be associated with many illnesses, including substance use disorders. Ketamine use disorder has significantly increased in Taiwan in recent years and may lead to physical and cognitive problems. Craving for ketamine is a risk factor for ketamine us...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689503/ https://www.ncbi.nlm.nih.gov/pubmed/33239629 http://dx.doi.org/10.1038/s41598-020-77631-9 |
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author | Yen, Cheng-Fang Lin, Huang-Chi Ko, Chih-Hung Wu, Hung-Chi Hsu, Chih-Yao Wang, Peng-Wei |
author_facet | Yen, Cheng-Fang Lin, Huang-Chi Ko, Chih-Hung Wu, Hung-Chi Hsu, Chih-Yao Wang, Peng-Wei |
author_sort | Yen, Cheng-Fang |
collection | PubMed |
description | Sleep problems are common in Taiwan. Poor sleep may be associated with many illnesses, including substance use disorders. Ketamine use disorder has significantly increased in Taiwan in recent years and may lead to physical and cognitive problems. Craving for ketamine is a risk factor for ketamine use and relapse, and poor sleep quality may increase craving. This study aimed to explore the mediating effects of craving on the relationship between poor sleep quality and ketamine use. Demographic data, sleep quality, severity of dependence and craving were recorded for current ketamine users and abstinent ketamine users. Mediation analysis was used to examine the mediating effect of craving on the relationship between poor sleep and ketamine use. This study enrolled 414 current ketamine users with ketamine use disorder, 238 current ketamine users without ketamine use disorder, and 102 abstinent ketamine users with ketamine use disorder. Compared with healthy controls, all ketamine users had poor sleep quality. Poor sleep quality was associated with the initiation of and dependence on ketamine use. Craving can mediate the relationship between poor sleep quality and ketamine use. Poor sleep quality remains a problem for those abstaining from ketamine use. Poor sleep quality in ketamine users is an important issue because it is directly and indirectly through craving associated with ketamine use. |
format | Online Article Text |
id | pubmed-7689503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76895032020-11-27 Sleep quality among individuals with ketamine use and the mediating role of craving Yen, Cheng-Fang Lin, Huang-Chi Ko, Chih-Hung Wu, Hung-Chi Hsu, Chih-Yao Wang, Peng-Wei Sci Rep Article Sleep problems are common in Taiwan. Poor sleep may be associated with many illnesses, including substance use disorders. Ketamine use disorder has significantly increased in Taiwan in recent years and may lead to physical and cognitive problems. Craving for ketamine is a risk factor for ketamine use and relapse, and poor sleep quality may increase craving. This study aimed to explore the mediating effects of craving on the relationship between poor sleep quality and ketamine use. Demographic data, sleep quality, severity of dependence and craving were recorded for current ketamine users and abstinent ketamine users. Mediation analysis was used to examine the mediating effect of craving on the relationship between poor sleep and ketamine use. This study enrolled 414 current ketamine users with ketamine use disorder, 238 current ketamine users without ketamine use disorder, and 102 abstinent ketamine users with ketamine use disorder. Compared with healthy controls, all ketamine users had poor sleep quality. Poor sleep quality was associated with the initiation of and dependence on ketamine use. Craving can mediate the relationship between poor sleep quality and ketamine use. Poor sleep quality remains a problem for those abstaining from ketamine use. Poor sleep quality in ketamine users is an important issue because it is directly and indirectly through craving associated with ketamine use. Nature Publishing Group UK 2020-11-25 /pmc/articles/PMC7689503/ /pubmed/33239629 http://dx.doi.org/10.1038/s41598-020-77631-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yen, Cheng-Fang Lin, Huang-Chi Ko, Chih-Hung Wu, Hung-Chi Hsu, Chih-Yao Wang, Peng-Wei Sleep quality among individuals with ketamine use and the mediating role of craving |
title | Sleep quality among individuals with ketamine use and the mediating role of craving |
title_full | Sleep quality among individuals with ketamine use and the mediating role of craving |
title_fullStr | Sleep quality among individuals with ketamine use and the mediating role of craving |
title_full_unstemmed | Sleep quality among individuals with ketamine use and the mediating role of craving |
title_short | Sleep quality among individuals with ketamine use and the mediating role of craving |
title_sort | sleep quality among individuals with ketamine use and the mediating role of craving |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689503/ https://www.ncbi.nlm.nih.gov/pubmed/33239629 http://dx.doi.org/10.1038/s41598-020-77631-9 |
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