Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

BACKGROUND: Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate microRNA transfer from liver to kidney. METHODS: Dicer(flox/flox) mice were treated with a Cre recombinase-expressing...

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Detalles Bibliográficos
Autores principales: Matthews, Olivia, Morrison, Emma E., Tranter, John D., Starkey Lewis, Philip, Toor, Iqbal S., Srivastava, Abhishek, Sargeant, Rebecca, Rollison, Helen, Matchett, Kylie P., Kendall, Timothy J., Gray, Gillian A., Goldring, Chris, Park, Kevin, Denby, Laura, Dhaun, Neeraj, Bailey, Matthew A., Henderson, Neil C., Williams, Dominic, Dear, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689533/
https://www.ncbi.nlm.nih.gov/pubmed/33232872
http://dx.doi.org/10.1016/j.ebiom.2020.103092

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