Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy

Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangioc...

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Detalles Bibliográficos
Autores principales: Mahpour, Amin, Mullen, Alan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689550/
https://www.ncbi.nlm.nih.gov/pubmed/33294829
http://dx.doi.org/10.1016/j.jhepr.2020.100177
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author Mahpour, Amin
Mullen, Alan C.
author_facet Mahpour, Amin
Mullen, Alan C.
author_sort Mahpour, Amin
collection PubMed
description Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes.
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spelling pubmed-76895502020-12-07 Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy Mahpour, Amin Mullen, Alan C. JHEP Rep Review Long non-coding RNAs (lncRNAs) are important biological mediators that regulate numerous cellular processes. New experimental evidence suggests that lncRNAs play essential roles in liver development, normal liver physiology, fibrosis, and malignancy, including hepatocellular carcinoma and cholangiocarcinoma. In this review, we summarise our current understanding of the function of lncRNAs in the liver in both health and disease, as well as discuss approaches that could be used to target these non-coding transcripts for therapeutic purposes. Elsevier 2020-09-03 /pmc/articles/PMC7689550/ /pubmed/33294829 http://dx.doi.org/10.1016/j.jhepr.2020.100177 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Mahpour, Amin
Mullen, Alan C.
Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
title Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
title_full Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
title_fullStr Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
title_full_unstemmed Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
title_short Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy
title_sort our emerging understanding of the roles of long non-coding rnas in normal liver function, disease, and malignancy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689550/
https://www.ncbi.nlm.nih.gov/pubmed/33294829
http://dx.doi.org/10.1016/j.jhepr.2020.100177
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