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Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China
BACKGROUND: Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients. METH...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689638/ https://www.ncbi.nlm.nih.gov/pubmed/33243228 http://dx.doi.org/10.1186/s12931-020-01580-0 |
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author | Zhang, Siqin Liu, Lin Yang, Bin Li, Rou Luo, Jianhua Huang, Jing Long, Yanjun Huang, Ying Zhou, Jianping Zha, Yan Zhang, Xiangyan |
author_facet | Zhang, Siqin Liu, Lin Yang, Bin Li, Rou Luo, Jianhua Huang, Jing Long, Yanjun Huang, Ying Zhou, Jianping Zha, Yan Zhang, Xiangyan |
author_sort | Zhang, Siqin |
collection | PubMed |
description | BACKGROUND: Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients. METHODS: In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. RESULTS: Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension, diabetes, and thyroid disease (P < 0.05). Leukopenia was present in 32.1% of the convalescent patients and lymphocytopenia was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults than in children (40.2% vs 13.6%, P = 0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis. No significant differences were observed in the positive rate of IgG and/or IgM antibodies between severe and non-severe patients. CONCLUSION: Leukopenia, lymphopenia, ground-glass opacity, and fibrosis are common in discharged severe COVID-19 patients, and liver injury is common in discharged adult patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients. |
format | Online Article Text |
id | pubmed-7689638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76896382020-11-27 Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China Zhang, Siqin Liu, Lin Yang, Bin Li, Rou Luo, Jianhua Huang, Jing Long, Yanjun Huang, Ying Zhou, Jianping Zha, Yan Zhang, Xiangyan Respir Res Research BACKGROUND: Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients. METHODS: In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. RESULTS: Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension, diabetes, and thyroid disease (P < 0.05). Leukopenia was present in 32.1% of the convalescent patients and lymphocytopenia was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults than in children (40.2% vs 13.6%, P = 0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis. No significant differences were observed in the positive rate of IgG and/or IgM antibodies between severe and non-severe patients. CONCLUSION: Leukopenia, lymphopenia, ground-glass opacity, and fibrosis are common in discharged severe COVID-19 patients, and liver injury is common in discharged adult patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients. BioMed Central 2020-11-26 2020 /pmc/articles/PMC7689638/ /pubmed/33243228 http://dx.doi.org/10.1186/s12931-020-01580-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhang, Siqin Liu, Lin Yang, Bin Li, Rou Luo, Jianhua Huang, Jing Long, Yanjun Huang, Ying Zhou, Jianping Zha, Yan Zhang, Xiangyan Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title | Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_full | Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_fullStr | Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_full_unstemmed | Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_short | Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_sort | clinical characteristics of 134 convalescent patients with covid-19 in guizhou, china |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689638/ https://www.ncbi.nlm.nih.gov/pubmed/33243228 http://dx.doi.org/10.1186/s12931-020-01580-0 |
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