Superiority of an Asymmetric Perylene Diimide in Terms of Hydrosolubility, G-Quadruplex Binding, Cellular Uptake, and Telomerase Inhibition in Prostate Cancer Cells

[Image: see text] Perylene diimide (PDI) derivatives have been studied as G-quadruplex ligands that suppress telomerase activity by facilitating G-quadruplex formation of telomeric DNA and the hTERT promoter. PIPER, the prototypical PDI, reduces telomerase activity in lung and prostate cancer cells,...

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Detalles Bibliográficos
Autores principales: Summart, Ratasark, Thaichana, Pak, Supan, Jutharat, Meepowpan, Puttinan, Lee, T. Randall, Tuntiwechapikul, Wirote
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689663/
https://www.ncbi.nlm.nih.gov/pubmed/33251409
http://dx.doi.org/10.1021/acsomega.0c03505

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