TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics

DNA‐encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or “hot spot”, regions of protein–protein interactions. A DNA‐encoded combinatorial peptoid library w...

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Detalles Bibliográficos
Autores principales: Kunig, Verena B. K., Potowski, Marco, Akbarzadeh, Mohammad, Klika Škopić, Mateja, dos Santos Smith, Denise, Arendt, Lukas, Dormuth, Ina, Adihou, Hélène, Andlovic, Blaž, Karatas, Hacer, Shaabani, Shabnam, Zarganes‐Tzitzikas, Tryfon, Neochoritis, Constantinos G., Zhang, Ran, Groves, Matthew, Guéret, Stéphanie M., Ottmann, Christian, Rahnenführer, Jörg, Fried, Roland, Dömling, Alexander, Brunschweiger, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689693/
https://www.ncbi.nlm.nih.gov/pubmed/32537835
http://dx.doi.org/10.1002/anie.202006280

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