Prediction of Drug Exposure in Critically Ill Encephalopathic Neonates Treated With Therapeutic Hypothermia Based on a Pooled Population Pharmacokinetic Analysis of Seven Drugs and Five Metabolites

Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure is dependent on body size and maturation but can also be influenced by factors related to disease and treatment. A better understanding of underlying pharmacokinetic principles is essential to guide...

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Detalles Bibliográficos
Autores principales: Favié, Laurent M. A., de Haan, Timo R., Bijleveld, Yuma A., Rademaker, Carin M. A., Egberts, Toine C. G., Nuytemans, Debbie H. G. M., Mathôt, Ron A. A., Groenendaal, Floris, Huitema, Alwin D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689752/
https://www.ncbi.nlm.nih.gov/pubmed/32463940
http://dx.doi.org/10.1002/cpt.1917

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