Improving the analytical toolbox to investigate copurifying host cell proteins presence: N‐(4)‐(β‐acetylglucosaminyl)‐ l‐asparaginase case study

Levels of host cell proteins (HCPs) in purification intermediates and drug substances (DS) of monoclonal antibodies (mAbs) must be carefully monitored for the production of safe and efficacious biotherapeutics. During the development of mAb1, an immunoglobulin G1 product, unexpected results generate...

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Detalles Bibliográficos
Autores principales: Clavier, Séverine, Fougeron, Delphine, Petrovic, Suzana, Elmaleh, Hagit, Fourneaux, Céline, Bugnazet, Dawid, Duffieux, Francis, Masiero, Alessandro, Mitra‐Kaushik, Shibani, Genet, Bruno, Fromentin, Yann, Kreiss, Patrick, Laborderie, Bénédicte, Brault, Dominique, Menet, Jean‐Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689792/
https://www.ncbi.nlm.nih.gov/pubmed/32706388
http://dx.doi.org/10.1002/bit.27514

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