Cargando…
Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review
Psoriasis is a long-lasting, noncontagious chronic inflammatory disease of skin and joints. Previous epidemiological studies have demonstrated that psoriatic patients have a shorter life expectancy, mainly due to cardiovascular (CV) events with a higher prevalence of cardiovascular risk factors like...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689809/ https://www.ncbi.nlm.nih.gov/pubmed/33262910 http://dx.doi.org/10.7759/cureus.11173 |
_version_ | 1783613935258173440 |
---|---|
author | Valaiyaduppu Subas, Sharathshiva Mishra, Vinayak Busa, Vishal Antony, Ishan Marudhai, Suganya Patel, Mauli Cancarevic, Ivan |
author_facet | Valaiyaduppu Subas, Sharathshiva Mishra, Vinayak Busa, Vishal Antony, Ishan Marudhai, Suganya Patel, Mauli Cancarevic, Ivan |
author_sort | Valaiyaduppu Subas, Sharathshiva |
collection | PubMed |
description | Psoriasis is a long-lasting, noncontagious chronic inflammatory disease of skin and joints. Previous epidemiological studies have demonstrated that psoriatic patients have a shorter life expectancy, mainly due to cardiovascular (CV) events with a higher prevalence of cardiovascular risk factors like dyslipidemia, diabetes mellitus, insulin resistance, obesity, and hypertension. Besides these risk factors, psoriasis likely plays an independent role in increasing CV events probably due to the chronic inflammatory state. This literature review aims to summarize the mechanism of atherosclerosis formation, CV risk factors, tools to diagnose subclinical atherosclerosis, and the effects of various therapies in psoriatic patients to prevent cardiovascular-related deaths in psoriasis. This review was performed by searching the relevant articles in PubMed and Google Scholar databases without including any exclusion criteria and time limitations. Our review documented that psoriatic patients are at increased risk of CV events due to chronic inflammatory profile and the associated CV risk factors. Also, anti-inflammatory therapies may prevent early subclinical atherosclerotic vascular changes reducing cardiovascular events. However, the available studies lack to establish the exact targets for CV risk factors, to assess the clinical importance of screening for subclinical vascular changes and the impact of anti-inflammatory therapies on CV risk profile in psoriatic patients. This heightened awareness about the CV involvement in psoriasis should encourage conducting large, well planned comprehensive studies to address these issues that can reduce cardiovascular morbidity and mortality. |
format | Online Article Text |
id | pubmed-7689809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-76898092020-11-30 Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review Valaiyaduppu Subas, Sharathshiva Mishra, Vinayak Busa, Vishal Antony, Ishan Marudhai, Suganya Patel, Mauli Cancarevic, Ivan Cureus Cardiology Psoriasis is a long-lasting, noncontagious chronic inflammatory disease of skin and joints. Previous epidemiological studies have demonstrated that psoriatic patients have a shorter life expectancy, mainly due to cardiovascular (CV) events with a higher prevalence of cardiovascular risk factors like dyslipidemia, diabetes mellitus, insulin resistance, obesity, and hypertension. Besides these risk factors, psoriasis likely plays an independent role in increasing CV events probably due to the chronic inflammatory state. This literature review aims to summarize the mechanism of atherosclerosis formation, CV risk factors, tools to diagnose subclinical atherosclerosis, and the effects of various therapies in psoriatic patients to prevent cardiovascular-related deaths in psoriasis. This review was performed by searching the relevant articles in PubMed and Google Scholar databases without including any exclusion criteria and time limitations. Our review documented that psoriatic patients are at increased risk of CV events due to chronic inflammatory profile and the associated CV risk factors. Also, anti-inflammatory therapies may prevent early subclinical atherosclerotic vascular changes reducing cardiovascular events. However, the available studies lack to establish the exact targets for CV risk factors, to assess the clinical importance of screening for subclinical vascular changes and the impact of anti-inflammatory therapies on CV risk profile in psoriatic patients. This heightened awareness about the CV involvement in psoriasis should encourage conducting large, well planned comprehensive studies to address these issues that can reduce cardiovascular morbidity and mortality. Cureus 2020-10-26 /pmc/articles/PMC7689809/ /pubmed/33262910 http://dx.doi.org/10.7759/cureus.11173 Text en Copyright © 2020, Valaiyaduppu Subas et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Valaiyaduppu Subas, Sharathshiva Mishra, Vinayak Busa, Vishal Antony, Ishan Marudhai, Suganya Patel, Mauli Cancarevic, Ivan Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review |
title | Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review |
title_full | Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review |
title_fullStr | Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review |
title_full_unstemmed | Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review |
title_short | Cardiovascular Involvement in Psoriasis, Diagnosing Subclinical Atherosclerosis, Effects of Biological and Non-Biological Therapy: A Literature Review |
title_sort | cardiovascular involvement in psoriasis, diagnosing subclinical atherosclerosis, effects of biological and non-biological therapy: a literature review |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689809/ https://www.ncbi.nlm.nih.gov/pubmed/33262910 http://dx.doi.org/10.7759/cureus.11173 |
work_keys_str_mv | AT valaiyaduppusubassharathshiva cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview AT mishravinayak cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview AT busavishal cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview AT antonyishan cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview AT marudhaisuganya cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview AT patelmauli cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview AT cancarevicivan cardiovascularinvolvementinpsoriasisdiagnosingsubclinicalatherosclerosiseffectsofbiologicalandnonbiologicaltherapyaliteraturereview |