Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death

Of the ~80 putative toxin‐antitoxin (TA) modules encoded by the bacterial pathogen Mycobacterium tuberculosis (Mtb), three contain antitoxins essential for bacterial viability. One of these, Rv0060 (DNA ADP‐ribosyl glycohydrolase, DarG(Mtb)), functions along with its cognate toxin Rv0059 (DNA ADP‐ri...

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Detalles Bibliográficos
Autores principales: Zaveri, Anisha, Wang, Ruojun, Botella, Laure, Sharma, Ritu, Zhu, Linnan, Wallach, Joshua B., Song, Naomi, Jansen, Robert S., Rhee, Kyu Y., Ehrt, Sabine, Schnappinger, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689832/
https://www.ncbi.nlm.nih.gov/pubmed/32634279
http://dx.doi.org/10.1111/mmi.14571

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