Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach

Aristolochic acid I (AAI) is a well‐known genotoxic kidney carcinogen. Metabolic conversion of AAI into the DNA‐reactive aristolactam‐nitrenium ion is involved in the mode of action of tumor formation. This study aims to predict in vivo AAI‐DNA adduct formation in the kidney of rat, mouse and human...

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Detalles Bibliográficos
Autores principales: Abdullah, Rozaini, Wesseling, Sebastiaan, Spenkelink, Bert, Louisse, Jochem, Punt, Ans, Rietjens, Ivonne M.C.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689901/
https://www.ncbi.nlm.nih.gov/pubmed/33034907
http://dx.doi.org/10.1002/jat.4024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689901/
https://www.ncbi.nlm.nih.gov/pubmed/33034907
http://dx.doi.org/10.1002/jat.4024

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