Cargando…

Advanced design and development of nanoparticle/microparticle dual-drug combination lactose carrier-free dry powder inhalation aerosols

Rationale: lactose is the only FDA-approved carrier for dry powder inhaler (DPI) formulations in the US. Lactose carrier-based DPI products are contraindicated in patients with a known lactose allergy. Hence, inhaler formulations without lactose will benefit lactose allergic asthmatics. Objectives:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muralidharan, Priya, Mallory, Evan K., Malapit, Monica, Phan, Hanna, Ledford, Julie G., Hayes, Don, Mansour, Heidi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689944/ https://www.ncbi.nlm.nih.gov/pubmed/33391731 http://dx.doi.org/10.1039/d0ra07203f

Ejemplares similares

Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers
por: Muralidharan, Priya, et al.
Publicado: (2014)

Effect of compression pressure on inhalation grade lactose as carrier for dry powder inhalations
por: Raut, Neha Sureshrao, et al.
Publicado: (2016)

Advanced Microparticulate/Nanoparticulate Respirable Dry Powders of a Selective RhoA/Rho Kinase (Rock) Inhibitor for Targeted Pulmonary Inhalation Aerosol Delivery
por: Muralidharan, Priya, et al.
Publicado: (2021)

Co-spraying of carriers (mannitol-lactose) as a method to improve aerosolization performance of salbutamol sulfate dry powder inhaler
por: Ferdynand, Mickey Socrates, et al.
Publicado: (2020)

Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery
por: Wu, Xiao, et al.
Publicado: (2013)

Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling
por: Kou, Xiang, et al.
Publicado: (2017)

Design, characterization, and aerosolization of organic solution advanced spray-dried moxifloxacin and ofloxacin dipalmitoylphosphatidylcholine (DPPC) microparticulate/nanoparticulate powders for pulmonary inhalation aerosol delivery
por: Duan, Jinghua, et al.
Publicado: (2013)

Preparation and physicochemical characterization of spray-dried and jet-milled microparticles containing bosentan hydrate for dry powder inhalation aerosols
por: Lee, Hyo-Jung, et al.
Publicado: (2016)

Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers
por: Acosta, Maria F., et al.
Publicado: (2020)

Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying
por: Xi, Quan, et al.
Publicado: (2023)

Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles and nanoparticles for targeted respiratory nanomedicine delivery as dry powder inhalation aerosols
por: Meenach, Samantha A, et al.
Publicado: (2013)

Impact of Leucine and Magnesium Stearate on the Physicochemical Properties and Aerosolization Behavior of Wet Milled Inhalable Ibuprofen Microparticles for Developing Dry Powder Inhaler Formulation
por: Sharif, Shahjabeen, et al.
Publicado: (2023)

Design and development of innovative microparticulate/nanoparticulate inhalable dry powders of a novel synthetic trifluorinated chalcone derivative and Nrf2 agonist
por: Muralidharan, Priya, et al.
Publicado: (2020)

Amorphicity and Aerosolization of Soluplus-Based Inhalable Spray Dried Powders
por: Adhikari, Bishal Raj, et al.
Publicado: (2022)

Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation
por: Peng, Tingting, et al.
Publicado: (2017)

Carrier-Free Inhalable Dry Microparticles of Celecoxib: Use of the Electrospraying Technique
por: Jahangiri, Azin, et al.
Publicado: (2023)

Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations
por: Knap, Karolina, et al.
Publicado: (2022)

Influence of physical properties of carrier on the performance of dry powder inhalers
por: Peng, Tingting, et al.
Publicado: (2016)

Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
por: Mehta, Piyush
Publicado: (2018)

Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
por: Thiyagarajan, Durairaj, et al.
Publicado: (2021)

Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation
por: Xia, Yun, et al.
Publicado: (2019)

Effect of Lactose Pseudopolymorphic Transition on the Aerosolization Performance of Drug/Carrier Mixtures
por: Della Bella, Andrea, et al.
Publicado: (2019)

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation
por: Kwon, Yong-Bin, et al.
Publicado: (2020)

Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α-Lactose Monohydrate
por: Ma, Cai Y., et al.
Publicado: (2023)

Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1—7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers
por: Alabsi, Wafaa, et al.
Publicado: (2021)

The Optimisation of Carrier Selection in Dry Powder Inhaler Formulation and the Role of Surface Energetics
por: Abiona, Olaitan, et al.
Publicado: (2022)

Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy
por: Acosta, Maria F., et al.
Publicado: (2021)

Critical physicochemical attributes of chitosan nanoparticles admixed lactose-PEG 3000 microparticles in pulmonary inhalation
por: Alhajj, Nasser, et al.
Publicado: (2020)

The effect of exhalation before the inhalation of dry powder aerosol drugs on the breathing parameters, emitted doses and aerosol size distributions
por: Farkas, Árpád, et al.
Publicado: (2023)

State of the Art in Capsule-Based Dry Powder Inhalers: Deagglomeration Techniques and the Consequences for Formulation Aerosolization
por: Groß, Roman, et al.
Publicado: (2022)

Optimization and Scale Up of Spray Dried CPZEN-45 Aerosol Powders for Inhaled Tuberculosis Treatment
por: Stewart, Ian E., et al.
Publicado: (2022)

Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations
por: Molina, Carlos, et al.
Publicado: (2017)

Lactose-Containing Dry-Powder Inhalers for Patients with Cow’s Milk Protein Allergy—The Conundrum; A National Survey of Pediatric Pulmonologists and Allergologists
por: Bar-On, Ophir, et al.
Publicado: (2022)

Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In Vitro–In Silico Approach
por: Pinto, Joana T., et al.
Publicado: (2021)

Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach
por: Karimi, Keyhaneh, et al.
Publicado: (2016)

Design and physicochemical characterization of advanced spray-dried tacrolimus multifunctional particles for inhalation
por: Wu, Xiao, et al.
Publicado: (2013)

Inhaled medical aerosols by nebulizer delivery in pulmonary hypertension
por: Mansour, Heidi M.
Publicado: (2018)

The Effect of Solvent Treatment on the Performance of Various Carriers in Dry Powder Inhalations Containing Salbutamol Sulphate
por: Siahai Shadbad, Mohammad Reza, et al.
Publicado: (2013)

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
por: Phillips, Jonathan E., et al.
Publicado: (2017)

Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations
por: Shepard, Kimberly B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c5rpmg1tql9j45s5at40kfnr79