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Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis

BACKGROUND: Gestational weight gain has been associated with some adverse perinatal outcomes, but few studies have examined the association between gestational weight gain and offspring’s cognition and their conclusions are inconsistent. Our systematic review and meta-analysis aimed to synthesize th...

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Autores principales: Martínez-Hortelano, Jose Alberto, Álvarez-Bueno, Celia, Cavero-Redondo, Iván, Herráiz-Adillo, Ángel, Berlanga-Macías, Carlos, Martínez-Vizcaíno, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690030/
https://www.ncbi.nlm.nih.gov/pubmed/33243183
http://dx.doi.org/10.1186/s12887-020-02429-7
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author Martínez-Hortelano, Jose Alberto
Álvarez-Bueno, Celia
Cavero-Redondo, Iván
Herráiz-Adillo, Ángel
Berlanga-Macías, Carlos
Martínez-Vizcaíno, Vicente
author_facet Martínez-Hortelano, Jose Alberto
Álvarez-Bueno, Celia
Cavero-Redondo, Iván
Herráiz-Adillo, Ángel
Berlanga-Macías, Carlos
Martínez-Vizcaíno, Vicente
author_sort Martínez-Hortelano, Jose Alberto
collection PubMed
description BACKGROUND: Gestational weight gain has been associated with some adverse perinatal outcomes, but few studies have examined the association between gestational weight gain and offspring’s cognition and their conclusions are inconsistent. Our systematic review and meta-analysis aimed to synthesize the evidence regarding the association between gestational weight gain and offspring’s cognitive skills. METHODS: In this systematic review and meta-analysis (PROSPERO number, CRD42017073266), we systematically searched MEDLINE, EMBASE, Web of Science and the Cochrane Library for studies examining association between gestational weight gain and offspring’s cognitive skills, without restriction in study design or language. Two reviewers extracted in an independent way the data. The Quality of Reporting of Observational Longitudinal Research scale was used to assess the quality of included studies. Effect size (ES) for adjusted models and their corresponding 95% confidence intervals were calculated for (i) intelligence quotient, (ii) language related skills and (iii) mathematic related skills comparing offspring’s cognitive skills when gestational weight gain was within recommendations (as reference) with those from mothers whose gestational weight gain was above or below the recommendations. RESULTS: Thirteen studies were included. There was a positive trend that associated gestational weight gain above recommendations with better offspring’s intelligence quotient, although not statistically significant (ES 0.02, 95% CI -0.00, 0.05; I(2) = 0.00%). CONCLUSIONS: There is a not significant positive association between gestational weight gain above recommendations and intelligence quotient and some studies reported associations between gestational weight gain and offspring’s cognitive skills. Our analyses confirm a wide variability in the results of studies published so far and highlights the need for conducting studies including specific samples of pregnant women by pre-pregnancy body mass index and trimester of pregnancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-020-02429-7.
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spelling pubmed-76900302020-11-30 Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis Martínez-Hortelano, Jose Alberto Álvarez-Bueno, Celia Cavero-Redondo, Iván Herráiz-Adillo, Ángel Berlanga-Macías, Carlos Martínez-Vizcaíno, Vicente BMC Pediatr Research Article BACKGROUND: Gestational weight gain has been associated with some adverse perinatal outcomes, but few studies have examined the association between gestational weight gain and offspring’s cognition and their conclusions are inconsistent. Our systematic review and meta-analysis aimed to synthesize the evidence regarding the association between gestational weight gain and offspring’s cognitive skills. METHODS: In this systematic review and meta-analysis (PROSPERO number, CRD42017073266), we systematically searched MEDLINE, EMBASE, Web of Science and the Cochrane Library for studies examining association between gestational weight gain and offspring’s cognitive skills, without restriction in study design or language. Two reviewers extracted in an independent way the data. The Quality of Reporting of Observational Longitudinal Research scale was used to assess the quality of included studies. Effect size (ES) for adjusted models and their corresponding 95% confidence intervals were calculated for (i) intelligence quotient, (ii) language related skills and (iii) mathematic related skills comparing offspring’s cognitive skills when gestational weight gain was within recommendations (as reference) with those from mothers whose gestational weight gain was above or below the recommendations. RESULTS: Thirteen studies were included. There was a positive trend that associated gestational weight gain above recommendations with better offspring’s intelligence quotient, although not statistically significant (ES 0.02, 95% CI -0.00, 0.05; I(2) = 0.00%). CONCLUSIONS: There is a not significant positive association between gestational weight gain above recommendations and intelligence quotient and some studies reported associations between gestational weight gain and offspring’s cognitive skills. Our analyses confirm a wide variability in the results of studies published so far and highlights the need for conducting studies including specific samples of pregnant women by pre-pregnancy body mass index and trimester of pregnancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-020-02429-7. BioMed Central 2020-11-26 /pmc/articles/PMC7690030/ /pubmed/33243183 http://dx.doi.org/10.1186/s12887-020-02429-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Martínez-Hortelano, Jose Alberto
Álvarez-Bueno, Celia
Cavero-Redondo, Iván
Herráiz-Adillo, Ángel
Berlanga-Macías, Carlos
Martínez-Vizcaíno, Vicente
Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
title Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
title_full Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
title_fullStr Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
title_full_unstemmed Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
title_short Gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
title_sort gestational weight gain and offspring’s cognitive skills: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690030/
https://www.ncbi.nlm.nih.gov/pubmed/33243183
http://dx.doi.org/10.1186/s12887-020-02429-7
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