Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer

N6-Methyladenosine (m(6)A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m(6)A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers. Worldwide, brea...

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Autores principales: Wang, Yanyan, Zhang, Yujie, Du, Yushen, Zhou, Meiqi, Hu, Yue, Zhang, Suzhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690038/
https://www.ncbi.nlm.nih.gov/pubmed/33292526
http://dx.doi.org/10.1186/s13578-020-00502-3
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author Wang, Yanyan
Zhang, Yujie
Du, Yushen
Zhou, Meiqi
Hu, Yue
Zhang, Suzhan
author_facet Wang, Yanyan
Zhang, Yujie
Du, Yushen
Zhou, Meiqi
Hu, Yue
Zhang, Suzhan
author_sort Wang, Yanyan
collection PubMed
description N6-Methyladenosine (m(6)A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m(6)A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers. Worldwide, breast cancer is the most prevalent cancer in female. It is a very heterogeneous disease characterized by genetic and epigenetic variations in tumor cells. Increasing evidence has shown that the dysregulation of m(6)A-related effectors, as methyltransferases, demethylases, and m(6)A binding proteins, is pivotal in breast cancer pathogenesis. In this review, we have summarized the most up-to-date research on the biological functions of m(6)A modification in breast cancer and have discussed the potential clinical applications and future directions of m(6)A modification as a biomarker as well as a therapeutic target of breast cancer.
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spelling pubmed-76900382020-11-30 Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer Wang, Yanyan Zhang, Yujie Du, Yushen Zhou, Meiqi Hu, Yue Zhang, Suzhan Cell Biosci Review N6-Methyladenosine (m(6)A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m(6)A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers. Worldwide, breast cancer is the most prevalent cancer in female. It is a very heterogeneous disease characterized by genetic and epigenetic variations in tumor cells. Increasing evidence has shown that the dysregulation of m(6)A-related effectors, as methyltransferases, demethylases, and m(6)A binding proteins, is pivotal in breast cancer pathogenesis. In this review, we have summarized the most up-to-date research on the biological functions of m(6)A modification in breast cancer and have discussed the potential clinical applications and future directions of m(6)A modification as a biomarker as well as a therapeutic target of breast cancer. BioMed Central 2020-11-25 /pmc/articles/PMC7690038/ /pubmed/33292526 http://dx.doi.org/10.1186/s13578-020-00502-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Yanyan
Zhang, Yujie
Du, Yushen
Zhou, Meiqi
Hu, Yue
Zhang, Suzhan
Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer
title Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer
title_full Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer
title_fullStr Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer
title_full_unstemmed Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer
title_short Emerging roles of N6-methyladenosine (m(6)A) modification in breast cancer
title_sort emerging roles of n6-methyladenosine (m(6)a) modification in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690038/
https://www.ncbi.nlm.nih.gov/pubmed/33292526
http://dx.doi.org/10.1186/s13578-020-00502-3
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