Cargando…
The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma
PURPOSE: To investigate the accuracy, dosimetric parameters, and safety of 3D-printing non-coplanar template (3D-PNCT)-assisted CT guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas METHODS AND MATERIALS: We enrolled 15 patien...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690097/ https://www.ncbi.nlm.nih.gov/pubmed/33239023 http://dx.doi.org/10.1186/s12957-020-02087-0 |
_version_ | 1783613999289466880 |
---|---|
author | Jiang, Weijuan Jiang, Ping Wei, Shuhua Jiang, Yuliang Ji, Zhe Sun, Haitao Fan, Jinghong Li, Weiyan Shao, Yuxia Wang, Junjie |
author_facet | Jiang, Weijuan Jiang, Ping Wei, Shuhua Jiang, Yuliang Ji, Zhe Sun, Haitao Fan, Jinghong Li, Weiyan Shao, Yuxia Wang, Junjie |
author_sort | Jiang, Weijuan |
collection | PubMed |
description | PURPOSE: To investigate the accuracy, dosimetric parameters, and safety of 3D-printing non-coplanar template (3D-PNCT)-assisted CT guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas METHODS AND MATERIALS: We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needle insertion position, angular, and the needle tip distance deviations of preoperative plan with that of intraoperative in brachytherapy treatment planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intraoperative real-time plan, and postoperative plan, including D90, D100 (the dose to 90% and 100% of the target volume), V100, V150, and V200 (the volume receives 100%, 150%, and 200% of the prescribed doses). The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), and homogeneity index (HI) of the targets were compared among preoperative plan, intraoperative real-time plan, and postoperative plan. The perioperation complications and RSI-BT-related toxicity were assessed. RESULTS: The median follow-up was 8.2 months (range 1–18.5 months). One patient was lost to follow-up after RSI-BT. Fourteen patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0–30). The mean angular deviation was 2.70 ± 3.00° (range, 0–20). The needle tip distance deviation was 6.90 ± 6.00 mm (range, − 30–28). D90 for preoperative plan, intraoperative plan, and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04, and 128.98 ± 22.75, respectively. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p = 0.036). Four lesions reached CR, six lesions reached PR, three lesions were SD, and three lesions were PD. Four patients with moderate pain became mild, and two with mild pain relieved completely after RSI-BT. The other parameters showed no differences among preoperative plan, intraoperative plan, and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side effects were observed. CONCLUSION: CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate, and feasible strategy for recurrent carcinomas located in the retroperitoneal regions. |
format | Online Article Text |
id | pubmed-7690097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76900972020-11-30 The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma Jiang, Weijuan Jiang, Ping Wei, Shuhua Jiang, Yuliang Ji, Zhe Sun, Haitao Fan, Jinghong Li, Weiyan Shao, Yuxia Wang, Junjie World J Surg Oncol Research PURPOSE: To investigate the accuracy, dosimetric parameters, and safety of 3D-printing non-coplanar template (3D-PNCT)-assisted CT guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas METHODS AND MATERIALS: We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needle insertion position, angular, and the needle tip distance deviations of preoperative plan with that of intraoperative in brachytherapy treatment planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intraoperative real-time plan, and postoperative plan, including D90, D100 (the dose to 90% and 100% of the target volume), V100, V150, and V200 (the volume receives 100%, 150%, and 200% of the prescribed doses). The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), and homogeneity index (HI) of the targets were compared among preoperative plan, intraoperative real-time plan, and postoperative plan. The perioperation complications and RSI-BT-related toxicity were assessed. RESULTS: The median follow-up was 8.2 months (range 1–18.5 months). One patient was lost to follow-up after RSI-BT. Fourteen patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0–30). The mean angular deviation was 2.70 ± 3.00° (range, 0–20). The needle tip distance deviation was 6.90 ± 6.00 mm (range, − 30–28). D90 for preoperative plan, intraoperative plan, and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04, and 128.98 ± 22.75, respectively. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p = 0.036). Four lesions reached CR, six lesions reached PR, three lesions were SD, and three lesions were PD. Four patients with moderate pain became mild, and two with mild pain relieved completely after RSI-BT. The other parameters showed no differences among preoperative plan, intraoperative plan, and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side effects were observed. CONCLUSION: CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate, and feasible strategy for recurrent carcinomas located in the retroperitoneal regions. BioMed Central 2020-11-25 /pmc/articles/PMC7690097/ /pubmed/33239023 http://dx.doi.org/10.1186/s12957-020-02087-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Jiang, Weijuan Jiang, Ping Wei, Shuhua Jiang, Yuliang Ji, Zhe Sun, Haitao Fan, Jinghong Li, Weiyan Shao, Yuxia Wang, Junjie The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma |
title | The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma |
title_full | The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma |
title_fullStr | The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma |
title_full_unstemmed | The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma |
title_short | The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma |
title_sort | accuracy and safety of ct-guided iodine-125 seed implantation assisted by 3d non-coplanar template for retroperitoneal recurrent carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690097/ https://www.ncbi.nlm.nih.gov/pubmed/33239023 http://dx.doi.org/10.1186/s12957-020-02087-0 |
work_keys_str_mv | AT jiangweijuan theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jiangping theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT weishuhua theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jiangyuliang theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jizhe theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT sunhaitao theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT fanjinghong theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT liweiyan theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT shaoyuxia theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT wangjunjie theaccuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jiangweijuan accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jiangping accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT weishuhua accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jiangyuliang accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT jizhe accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT sunhaitao accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT fanjinghong accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT liweiyan accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT shaoyuxia accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma AT wangjunjie accuracyandsafetyofctguidediodine125seedimplantationassistedby3dnoncoplanartemplateforretroperitonealrecurrentcarcinoma |