Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

BACKGROUND: Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important co...

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Detalles Bibliográficos
Autores principales: Alkan, H. Furkan, Vesely, Paul W., Hackl, Hubert, Foßelteder, Johannes, Schmidt, Daniel R., Vander Heiden, Matthew G., Pichler, Martin, Hoefler, Gerald, Bogner-Strauss, Juliane G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690131/
https://www.ncbi.nlm.nih.gov/pubmed/33292758
http://dx.doi.org/10.1186/s40170-020-00232-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690131/
https://www.ncbi.nlm.nih.gov/pubmed/33292758
http://dx.doi.org/10.1186/s40170-020-00232-7

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