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Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population

Little is known about the relationship between polyunsaturated fatty acids (PUFAs) and reactive oxygen species (ROS) in the general population. Therefore this study aimed to describe the association of PUFAs with ROS according to age and sex in the general population and to determine whether PUFA le...

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Autores principales: Suzuki, Nobuaki, Sawada, Kaori, Takahashi, Ippei, Matsuda, Motoko, Fukui, Shinji, Tokuyasu, Hidemasa, Shimizu, Hiroyasu, Yokoyama, Junichi, Akaike, Arata, Nakaji, Shigeyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690262/
https://www.ncbi.nlm.nih.gov/pubmed/33105547
http://dx.doi.org/10.3390/nu12113222
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author Suzuki, Nobuaki
Sawada, Kaori
Takahashi, Ippei
Matsuda, Motoko
Fukui, Shinji
Tokuyasu, Hidemasa
Shimizu, Hiroyasu
Yokoyama, Junichi
Akaike, Arata
Nakaji, Shigeyuki
author_facet Suzuki, Nobuaki
Sawada, Kaori
Takahashi, Ippei
Matsuda, Motoko
Fukui, Shinji
Tokuyasu, Hidemasa
Shimizu, Hiroyasu
Yokoyama, Junichi
Akaike, Arata
Nakaji, Shigeyuki
author_sort Suzuki, Nobuaki
collection PubMed
description Little is known about the relationship between polyunsaturated fatty acids (PUFAs) and reactive oxygen species (ROS) in the general population. Therefore this study aimed to describe the association of PUFAs with ROS according to age and sex in the general population and to determine whether PUFA levels are indicators of ROS. This cross-sectional study included 895 participants recruited from a 2015 community health project. Participants were divided into 6 groups based on sex and age (less than 45 years old (young), aged 45–64 years (middle-aged), and 65 years or older (old)) as follows: male, young (n = 136); middle-aged (n = 133); old (n = 82); female, young (n = 159); middle-aged (n = 228); and old (n = 157). The PUFAs measured were arachidonic acid (AA), dihomo gamma linolenic acid (DGLA), AA/DGLA ratio, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). ROS considered in the analysis were basal ROS and stimulated ROS levels. Multiple linear analyses showed: (1) significant correlations between PUFA levels, especially DGLA and AA/DGLA ratio, and neutrophil function in the young and middle-aged groups; (2) no significant correlations in old age groups for either sex. Because PUFAs have associated with the ROS production, recommendation for controlled PUFA intake from a young age should be considered.
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spelling pubmed-76902622020-11-27 Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population Suzuki, Nobuaki Sawada, Kaori Takahashi, Ippei Matsuda, Motoko Fukui, Shinji Tokuyasu, Hidemasa Shimizu, Hiroyasu Yokoyama, Junichi Akaike, Arata Nakaji, Shigeyuki Nutrients Article Little is known about the relationship between polyunsaturated fatty acids (PUFAs) and reactive oxygen species (ROS) in the general population. Therefore this study aimed to describe the association of PUFAs with ROS according to age and sex in the general population and to determine whether PUFA levels are indicators of ROS. This cross-sectional study included 895 participants recruited from a 2015 community health project. Participants were divided into 6 groups based on sex and age (less than 45 years old (young), aged 45–64 years (middle-aged), and 65 years or older (old)) as follows: male, young (n = 136); middle-aged (n = 133); old (n = 82); female, young (n = 159); middle-aged (n = 228); and old (n = 157). The PUFAs measured were arachidonic acid (AA), dihomo gamma linolenic acid (DGLA), AA/DGLA ratio, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). ROS considered in the analysis were basal ROS and stimulated ROS levels. Multiple linear analyses showed: (1) significant correlations between PUFA levels, especially DGLA and AA/DGLA ratio, and neutrophil function in the young and middle-aged groups; (2) no significant correlations in old age groups for either sex. Because PUFAs have associated with the ROS production, recommendation for controlled PUFA intake from a young age should be considered. MDPI 2020-10-22 /pmc/articles/PMC7690262/ /pubmed/33105547 http://dx.doi.org/10.3390/nu12113222 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suzuki, Nobuaki
Sawada, Kaori
Takahashi, Ippei
Matsuda, Motoko
Fukui, Shinji
Tokuyasu, Hidemasa
Shimizu, Hiroyasu
Yokoyama, Junichi
Akaike, Arata
Nakaji, Shigeyuki
Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population
title Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population
title_full Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population
title_fullStr Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population
title_full_unstemmed Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population
title_short Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population
title_sort association between polyunsaturated fatty acid and reactive oxygen species production of neutrophils in the general population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690262/
https://www.ncbi.nlm.nih.gov/pubmed/33105547
http://dx.doi.org/10.3390/nu12113222
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