Cargando…

Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a hypoxic microenvironment. Pancreatic stellate cells (PSC) are activated by hypoxia and promote excessive desmoplasia, further contributing to the development of hypoxia. We aimed to explore how hypoxia and stroma inter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Dajia, Steins, Anne, Klaassen, Remy, van der Zalm, Amber P., Bennink, Roel J., van Tienhoven, Geertjan, Besselink, Marc G., Bijlsma, Maarten F., van Laarhoven, Hanneke W. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690284/ https://www.ncbi.nlm.nih.gov/pubmed/33105540 http://dx.doi.org/10.3390/biomedicines8110444

Ejemplares similares

High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐1
por: Steins, Anne, et al.
Publicado: (2020)

Pathological validation and prognostic potential of quantitative MRI in the characterization of pancreas cancer: preliminary experience
por: Klaassen, Remy, et al.
Publicado: (2020)

Chemoradiation induces epithelial‐to‐mesenchymal transition in esophageal adenocarcinoma
por: Steins, Anne, et al.
Publicado: (2019)

Clinical Trials Targeting the Stroma in Pancreatic Cancer: A Systematic Review and Meta-Analysis
por: van Mackelenbergh, Madelaine G., et al.
Publicado: (2019)

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer Growth
por: Manoukian, Paul, et al.
Publicado: (2021)

Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems
por: Dijk, Frederike, et al.
Publicado: (2020)

Stromal SPOCK1 supports invasive pancreatic cancer growth
por: Veenstra, Veronique L., et al.
Publicado: (2017)

All eyes on the patient: the influence of oncologists’ nonverbal communication on breast cancer patients’ trust
por: Hillen, Marij A., et al.
Publicado: (2015)

Hypoxic Signalling in Tumour Stroma
por: Laitala, Anu, et al.
Publicado: (2018)

Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma
por: Ebbing, Eva A., et al.
Publicado: (2019)

The prognostic role of desmoplastic stroma in pancreatic ductal adenocarcinoma
por: Wang, Lai Mun, et al.
Publicado: (2015)

Immune features of the peritumoral stroma in pancreatic ductal adenocarcinoma
por: Ahmed, Azaz, et al.
Publicado: (2022)

Extracellular Influences: Molecular Subclasses and the Microenvironment in Pancreatic Cancer
por: Veenstra, Veronique L., et al.
Publicado: (2018)

Comparative Characterization of Stroma Cells and Ductal Epithelium in Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma
por: Helm, Ole, et al.
Publicado: (2014)

The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma
por: Houg, Demi S., et al.
Publicado: (2018)

Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma
por: Strijker, Marin, et al.
Publicado: (2019)

Is hyaluronan deposition in the stroma of pancreatic ductal adenocarcinoma of prognostic significance?
por: Gebauer, Florian, et al.
Publicado: (2017)

Local irradiation of patient-derived tumors in immunodeficient mice
por: van der Zalm, Amber P., et al.
Publicado: (2023)

Editorial: Translational Insights Into Pancreatic Ductal Adenocarcinoma
por: Bijlsma, Maarten F., et al.
Publicado: (2022)

Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma
por: Leppänen, Joni, et al.
Publicado: (2019)

Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer
por: Dings, Mark P.G., et al.
Publicado: (2022)

Rapid stromal remodeling by short‐term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma
por: Steins, Anne, et al.
Publicado: (2020)

Association between body composition, survival, and toxicity in advanced esophagogastric cancer patients receiving palliative chemotherapy
por: Dijksterhuis, Willemieke P.M., et al.
Publicado: (2019)

Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract
por: Damhofer, Helene, et al.
Publicado: (2015)

Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel
por: Steins, Anne, et al.
Publicado: (2017)

Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins
por: Liot, Sophie, et al.
Publicado: (2021)

Gemcitabine-Based Neoadjuvant Treatment in Borderline Resectable Pancreatic Ductal Adenocarcinoma: A Meta-Analysis of Individual Patient Data
por: Giovinazzo, Francesco, et al.
Publicado: (2020)

Soluble stroma‐related biomarkers of pancreatic cancer
por: Resovi, Andrea, et al.
Publicado: (2018)

Protease‐activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma
por: Tekin, Cansu, et al.
Publicado: (2021)

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma
por: Di Maggio, Francesco, et al.
Publicado: (2016)

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
por: Moffitt, Richard A., et al.
Publicado: (2015)

The tumor–stroma ratio and the immune microenvironment improve the prognostic prediction of pancreatic ductal adenocarcinoma
por: Lu, Mei, et al.
Publicado: (2023)

Dosimetric effects of anatomical changes during fractionated photon radiation therapy in pancreatic cancer patients
por: van der Horst, Astrid, et al.
Publicado: (2017)

Evaluating differences in respiratory motion estimates during radiotherapy: a single planning 4DMRI versus daily 4DMRI
por: den Boer, Duncan, et al.
Publicado: (2021)

Feasibility of CT radiomics to predict treatment response of individual liver metastases in esophagogastric cancer patients
por: Klaassen, Remy, et al.
Publicado: (2018)

ASO Author Reflections: Surgical Predictors for Survival in Patients Undergoing Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma
por: Korrel, Maarten, et al.
Publicado: (2020)

Comparison of six fit algorithms for the intra-voxel incoherent motion model of diffusion-weighted magnetic resonance imaging data of pancreatic cancer patients
por: Gurney-Champion, Oliver J., et al.
Publicado: (2018)

Genomic Landscape in Neoplasm-Like Stroma Reveals Distinct Prognostic Subtypes of Pancreatic Ductal Adenocarcinoma
por: Jiang, Jiahong, et al.
Publicado: (2021)

Tumor Stroma Area and Other Prognostic Factors in Pancreatic Ductal Adenocarcinoma Patients Submitted to Surgery
por: Amaral, Maria João, et al.
Publicado: (2023)

Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?
por: Slapak, Etienne J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bucejovef940fhprarkr4jnu3o