Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study

OBJECTIVE: To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes. DESIGN: Nationwide seroepidemiological study. SETTING: First wave of covid-19 pan...

Descripción completa

Detalles Bibliográficos
Autores principales: Pastor-Barriuso, Roberto, Pérez-Gómez, Beatriz, Hernán, Miguel A, Pérez-Olmeda, Mayte, Yotti, Raquel, Oteo-Iglesias, Jesús, Sanmartín, Jose L, León-Gómez, Inmaculada, Fernández-García, Aurora, Fernández-Navarro, Pablo, Cruz, Israel, Martín, Mariano, Delgado-Sanz, Concepción, Fernández de Larrea, Nerea, León Paniagua, Jose, Muñoz-Montalvo, Juan F, Blanco, Faustino, Larrauri, Amparo, Pollán, Marina, Aparicio Azcárraga, Pilar, Gutiérrez Fernández, Rodrigo, Mezcua Navarro, Saturnino, Molina, Marta, Salinero Hernández, Matías, Cuenca-Estrella, Manuel, León Paniagua, José, Gómez-Barroso, Diana, Avellón, Ana, Fedele, Giovanni, Oteo Iglesias, Jesús, Pérez Olmeda, María Teresa, Fernández Martínez, Maria Elena, Rodríguez-Cabrera, Francisco D, Padrones Fernández, Susana, Rumbao Aguirre, José Manuel, Navarro Marí, José M, Palop Borrás, Begoña, Pérez Jiménez, Ana Belén, Rodríguez-Iglesias, Manuel, Calvo Gascón, Ana María, Lou Alcaine, María Luz, Donate Suárez, Ignacio, Suárez Álvarez, Oscar, Rodríguez Pérez, Mercedes, Cases Sanchís, Margarita, Villafáfila Gomila, Carlos Javier, Carbo Saladrigas, Lluis, Hurtado Fernández, Adoración, Oliver, Antonio, Castro Feliciano, Elías, González Quintana, María Noemí, Barrasa Fernández, José María, Hernández Betancor, María Araceli, Hernández Febles, Melisa, Martín Martín, Leopoldo, López López, Luis-Mariano, Ugarte Miota, Teresa, De Benito Población, Inés, Celada Pérez, María Sagrario, Vallés Fernández, María Natalia, Maté Enríquez, Tomás, Villa Arranz, Miguel, Domínguez-Gil González, Marta, Fernández-Natal, Isabel, Megías Lobón, Gregoria, Muñoz Bellido, Juan Luis, Ciruela, Pilar, Mas i Casals, Ariadna, Doladé Botías, Maria, Marcos Maeso, M Angeles, Pérez del Campo, Dúnia, Félix de Castro, Antonio, Limón Ramírez, Ramón, Elías Retamosa, Maria Francisca, Rubio González, Manuela, Blanco Lobeiras, María Sinda, Fuentes Losada, Alberto, Aguilera, Antonio, Bou, German, Caro, Yolanda, Marauri, Noemí, Soria Blanco, Luis Miguel, del Cura González, Isabel, Hernández Pascual, Montserrat, Alonso Fernández, Roberto, Merino-Amador, Paloma, Cabrera Castro, Natalia, Tomás Lizcano, Aurora, Ramírez Almagro, Cristóbal, Segovia Hernández, Manuel, Ascunce Elizaga, Nieves, Ederra Sanz, María, Ezpeleta Baquedano, Carmen, Bustinduy Bascaran, Ana, Iglesias Tamayo, Susana, Elorduy Otazua, Luis, Benarroch Benarroch, Rebeca, Lopera Flores, Jesús, Vázquez de la Villa, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690290/
https://www.ncbi.nlm.nih.gov/pubmed/33246972
http://dx.doi.org/10.1136/bmj.m4509
Descripción
Sumario:OBJECTIVE: To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes. DESIGN: Nationwide seroepidemiological study. SETTING: First wave of covid-19 pandemic in Spain. PARTICIPANTS: Community dwelling individuals of all ages. MAIN OUTCOME MEASURES: The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61 098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020. RESULTS: The overall infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24 778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more. CONCLUSION: The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza.

Ejemplares similares