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Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF). TFF produces brittle matrix nanostructured aggregates that are sheared into...

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Detalles Bibliográficos
Autores principales: Sahakijpijarn, Sawittree, Moon, Chaeho, Koleng, John J., Christensen, Dale J., Williams, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690377/
https://www.ncbi.nlm.nih.gov/pubmed/33105618
http://dx.doi.org/10.3390/pharmaceutics12111002