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The Importance of Research on the Origin of SARS-CoV-2

The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also...

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Autores principales: Lundstrom, Kenneth, Seyran, Murat, Pizzol, Damiano, Adadi, Parise, Mohamed Abd El-Aziz, Tarek, Hassan, Sk. Sarif, Soares, Antonio, Kandimalla, Ramesh, Tambuwala, Murtaza M., Aljabali, Alaa A. A., Kumar Azad, Gajendra, Pal Choudhury, Pabitra, Uversky, Vladimir N., Sherchan, Samendra P., Uhal, Bruce D., Rezaei, Nima, Brufsky, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690418/
https://www.ncbi.nlm.nih.gov/pubmed/33105685
http://dx.doi.org/10.3390/v12111203
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author Lundstrom, Kenneth
Seyran, Murat
Pizzol, Damiano
Adadi, Parise
Mohamed Abd El-Aziz, Tarek
Hassan, Sk. Sarif
Soares, Antonio
Kandimalla, Ramesh
Tambuwala, Murtaza M.
Aljabali, Alaa A. A.
Kumar Azad, Gajendra
Pal Choudhury, Pabitra
Uversky, Vladimir N.
Sherchan, Samendra P.
Uhal, Bruce D.
Rezaei, Nima
Brufsky, Adam M.
author_facet Lundstrom, Kenneth
Seyran, Murat
Pizzol, Damiano
Adadi, Parise
Mohamed Abd El-Aziz, Tarek
Hassan, Sk. Sarif
Soares, Antonio
Kandimalla, Ramesh
Tambuwala, Murtaza M.
Aljabali, Alaa A. A.
Kumar Azad, Gajendra
Pal Choudhury, Pabitra
Uversky, Vladimir N.
Sherchan, Samendra P.
Uhal, Bruce D.
Rezaei, Nima
Brufsky, Adam M.
author_sort Lundstrom, Kenneth
collection PubMed
description The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational “hot spot” as only the D614G mutation has been identified from clinical isolates. As laboratory manipulation is highly unlikely for the origin of SARS-CoV-2, the current possibilities comprise either natural selection in animal host before zoonotic transfer or natural selection in humans following zoonotic transfer. In the former case, despite SARS-CoV-2 and bat RaTG13 showing 96% identity some pangolin Coronaviruses exhibit very high similarity to particularly the receptor-binding domain of SARS-CoV-2. In the latter case, it can be hypothesized that the SARS-CoV-2 genome has adapted during human-to-human transmission and based on available data, the isolated SARS-CoV-2 genomes derive from a common origin. Before the origin of SARS-CoV-2 can be confirmed additional research is required
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spelling pubmed-76904182020-11-27 The Importance of Research on the Origin of SARS-CoV-2 Lundstrom, Kenneth Seyran, Murat Pizzol, Damiano Adadi, Parise Mohamed Abd El-Aziz, Tarek Hassan, Sk. Sarif Soares, Antonio Kandimalla, Ramesh Tambuwala, Murtaza M. Aljabali, Alaa A. A. Kumar Azad, Gajendra Pal Choudhury, Pabitra Uversky, Vladimir N. Sherchan, Samendra P. Uhal, Bruce D. Rezaei, Nima Brufsky, Adam M. Viruses Editorial The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational “hot spot” as only the D614G mutation has been identified from clinical isolates. As laboratory manipulation is highly unlikely for the origin of SARS-CoV-2, the current possibilities comprise either natural selection in animal host before zoonotic transfer or natural selection in humans following zoonotic transfer. In the former case, despite SARS-CoV-2 and bat RaTG13 showing 96% identity some pangolin Coronaviruses exhibit very high similarity to particularly the receptor-binding domain of SARS-CoV-2. In the latter case, it can be hypothesized that the SARS-CoV-2 genome has adapted during human-to-human transmission and based on available data, the isolated SARS-CoV-2 genomes derive from a common origin. Before the origin of SARS-CoV-2 can be confirmed additional research is required MDPI 2020-10-22 /pmc/articles/PMC7690418/ /pubmed/33105685 http://dx.doi.org/10.3390/v12111203 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Lundstrom, Kenneth
Seyran, Murat
Pizzol, Damiano
Adadi, Parise
Mohamed Abd El-Aziz, Tarek
Hassan, Sk. Sarif
Soares, Antonio
Kandimalla, Ramesh
Tambuwala, Murtaza M.
Aljabali, Alaa A. A.
Kumar Azad, Gajendra
Pal Choudhury, Pabitra
Uversky, Vladimir N.
Sherchan, Samendra P.
Uhal, Bruce D.
Rezaei, Nima
Brufsky, Adam M.
The Importance of Research on the Origin of SARS-CoV-2
title The Importance of Research on the Origin of SARS-CoV-2
title_full The Importance of Research on the Origin of SARS-CoV-2
title_fullStr The Importance of Research on the Origin of SARS-CoV-2
title_full_unstemmed The Importance of Research on the Origin of SARS-CoV-2
title_short The Importance of Research on the Origin of SARS-CoV-2
title_sort importance of research on the origin of sars-cov-2
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690418/
https://www.ncbi.nlm.nih.gov/pubmed/33105685
http://dx.doi.org/10.3390/v12111203
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